The charged multivesicular body proteins, commonly designated CHMPs, belong to the vacuolar sorting protein family and function as chromatin-modifying proteins. CHMP1-6 are all components of ESCRT (endosomal sorting complex required for transport) I, II or III complexes. These complexes are crucial for sorting endosomal articles into multivesicular bodies (MVBs), as well as required for the formation of these bodies. CHMP3, also known as Vps24, associates directly with CHMP2 and CHMP4 for the disassembly of ESCRT-III complex in an ATP-dependent manner. During HIV-1 infection, the virus uses the ESCRT-III complex to mediate budding and exocytosis of viral proteins. Overexpression of CHMP3 strongly inhibits HIV-1 release. CHMP3 is expressed in brain, skeletal muscle, heart, lung, kidney and liver.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps CHMP3 (C-1) | sc-393541 | 200 µg/ml | $316.00 | |||
CHMP3 (C-1): m-IgG Fc BP-HRP Kit | sc-538241 | 200 µg Ab; 10 µg BP | $354.00 | |||
CHMP3 (C-1): m-IgGκ BP-HRP Kit | sc-535815 | 200 µg Ab; 40 µg BP | $354.00 | |||
CHMP3 (C-1): m-IgG2a BP-HRP Kit | sc-548245 | 200 µg Ab; 10 µg BP | $354.00 | |||
CHMP3 (C-1) peptide neutralisant | sc-393541 P | 100 µg/0.5 ml | $68.00 |