CD7 Antibody (M-T701): sc-19645

CD7 Antibody (M-T701) is a mouse monoclonal IgG1 antibody that detects CD7 in human samples through immunofluorescence (IF) and flow cytometry (FCM) applications. CD7 is a type I transmembrane glycoprotein that plays a crucial role in the immune system, particularly in T cell activation and differentiation. CD7 is predominantly expressed on pluripotential hematopoietic cells, most human thymocytes, and a subset of peripheral blood T cells, making CD7 an important marker for identifying pluripotential stem cell leukemias and T cell acute lymphocytic leukemia. CD7 is vital for the proper functioning of T cells, as CD7 is involved in the activation of T cells with γ/δ receptors, which are essential for immune responses against various pathogens. Notably, studies have shown that CD8 T cells from patients infected with HIV-1 exhibit significant down-regulation of CD7 expression compared to healthy individuals, highlighting CD7′s potential role in immune evasion during viral infections. Furthermore, CD7 is among the pan-T-cell antigens that are down-regulated in acute infectious mononucleosis, indicating CD7′s relevance in both normal and pathological immune responses. Anti-CD7 antibody (M-T701) is an invaluable tool for researchers studying T cell biology and related diseases.

The preferred CD7 antibody is CD7 Antibody (CBC.37): sc-59108.