CD24 Antibody (3H1143): sc-70600

CD24 Antibody (3H1143) is a mouse monoclonal IgG1 antibody that detects CD24 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD24 is a glycosylphosphatidylinositol (GPI)-anchored membrane sialoglycoprotein predominantly expressed on pro-B, pre-B, and mature B cells, with expression diminishing following B cell activation. CD24 is also present on granulocytes and a small subset of thymocytes and neuroblastomas, but remains absent in plasma cells. CD24 plays a crucial role in regulating B cell proliferation and differentiation, serving as a marker for B cell maturation and showing involvement in various hematological malignancies and solid tumors. A transition from apical to cytoplasmic staining of CD24 has been identified as a surrogate marker for stromal invasion in ovarian serous tumors of borderline malignancy. CD24′s expression pattern provides insights into B cell differentiation status, appearing on mature resting B cells but disappearing upon stimulation, highlighting CD24′s importance in understanding immune responses and potential therapeutic targets in cancer. Anti-CD24 antibody (3H1143) serves as an essential tool for researchers investigating B cell biology and tumor immunology.

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CD24 Antibody (3H1143) References:

1. CD24(+) cells fuel rapid tumor growth and display high metastatic capacity.  |  Rostoker, R., et al. 2015. Breast Cancer Res. 17: 78. PMID: 26040280
2. CD24 Modulates Chemosensitivity of MCF-7 Breast Cancer Cells.  |  Onishi, H., et al. 2017. Anticancer Res. 37: 561-565. PMID: 28179302
3. CD24 blunts the sensitivity of retinoblastoma to vincristine by modulating autophagy.  |  Sun, J., et al. 2020. Mol Oncol. 14: 1740-1759. PMID: 32394616
4. Knock-Down of CD24 in Astrocytes Aggravates Oxyhemoglobin-Induced Hippocampal Neuron Impairment.  |  Chen, XX., et al. 2022. Neurochem Res. 47: 590-600. PMID: 34665391
5. Dendritic cell expression of CD24 contributes to optimal priming of T lymphocytes in lymph nodes.  |  Zhang, X., et al. 2023. Front Immunol. 14: 1116749. PMID: 36969215
6. Inhaled Exosomes Genetically Manipulated to Overexpress CD24 (EXO-CD24) as a Compassionate Use in Severe ARDS Patients.  |  Green, O., et al. 2023. Biomedicines. 11: PMID: 37760963
7. IMM47, a humanized monoclonal antibody that targets CD24, exhibits exceptional anti-tumor efficacy by blocking the CD24/Siglec-10 interaction and can be used as monotherapy or in combination with anti-PD1 antibodies for cancer immunotherapy.  |  Li, S., et al. 2023. Antib Ther. 6: 240-252. PMID: 37846296
8. The safety and potential efficacy of exosomes overexpressing CD24 (EXO-CD24) in mild-moderate COVID-19 related ARDS.  |  Grigoropoulos, I., et al. 2024. Respir Res. 25: 151. PMID: 38561798
9. Integration of multiomics analyses reveals unique insights into CD24-mediated immunosuppressive tumor microenvironment of breast cancer.  |  Hu, H., et al. 2024. Inflamm Res. 73: 1047-1068. PMID: 38622285
10. The LAT1 inhibitor JPH203 suppresses the growth of castration-resistant prostate cancer through a CD24-mediated mechanism.  |  Saito, S., et al. 2024. Cancer Sci. 115: 2461-2472. PMID: 38655663

The preferred CD24 antibody is CD24 Antibody (SN3): sc-19585.