CD13 Antibody (WM15): sc-51522
- CD13 Antibody (WM15) is a mouse monoclonal IgG1, cited in 11 publications, provided at 100 µg/ml
- raised against human AML cells
- recommended for detection of CD13 of mouse, rat and human origin by IP, IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CD13 Antibody (WM15). This work is in progress.
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CD13 Antibody (WM15) is a mouse monoclonal IgG1 antibody that detects CD13 in mouse, rat, and human samples through applications such as immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD13, also known as aminopeptidase N, is a type II transmembrane glycoprotein predominantly expressed on myeloid cells, including monocytes, basophils, eosinophils, neutrophils, and various myeloid leukemias, as well as on certain epithelial cells, fibroblasts, and osteoclasts. CD13 functions as a zinc-binding metalloprotease, playing a crucial role in the digestion of peptides and the inactivation of regulatory peptides like enkephalins, which are important for pain modulation and stress response. CD13 is significant in cancer biology, as CD13 may enhance the invasive capacity and metastatic behavior of cancer cells, making CD13 a potential target for therapeutic intervention. Notably, the expression of basic fibroblast growth factor (bFGF) has been shown to upregulate CD13 in human melanoma cells by activating both the myeloid and epithelial CD13 promoters, highlighting CD13′s role in tumor progression and potential as a biomarker for cancer research. Anti-CD13 antibody (WM15) is an essential tool for researchers investigating the complex roles of CD13 in various biological processes and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD13 Antibody (WM15) References:
- CD13/aminopeptidase N and murine cytomegalovirus infection. | Kasman, LM. 2005. Virology. 334: 1-9. PMID: 15749117
- CD13 restricts TLR4 endocytic signal transduction in inflammation. | Ghosh, M., et al. 2015. J Immunol. 194: 4466-76. PMID: 25801433
- The pro-inflammatory cytokine 14-3-3ε is a ligand of CD13 in cartilage. | Nefla, M., et al. 2015. J Cell Sci. 128: 3250-62. PMID: 26208633
- Distinct Epitopes on CD13 Mediate Opposite Consequences for Cell Adhesion. | Garay-Canales, CA., et al. 2018. Biomed Res Int. 2018: 4093435. PMID: 29789790
- CD13 Inhibition Enhances Cytotoxic Effect of Chemotherapy Agents. | Zhang, J., et al. 2018. Front Pharmacol. 9: 1042. PMID: 30258365
- CD13 inhibition augments DR4-induced tumor cell death in a p-ERK1/2-independent manner. | Ni, J., et al. 2021. Cancer Biol Med. 18: 569-86. PMID: 33710811
- CD13 orients the apical-basal polarity axis necessary for lumen formation. | Wang, LT., et al. 2021. Nat Commun. 12: 4697. PMID: 34349123
- Cancer-specific glycosylation of CD13 impacts its detection and activity in preclinical cancer tissues. | Barnieh, FM., et al. 2023. iScience. 26: 108219. PMID: 37942010
- A novel aminopeptidase N/CD13 inhibitor selectively targets an endothelial form of CD13 after coupling to proteins. | Anderluzzi, G., et al. 2024. Cell Mol Life Sci. 81: 68. PMID: 38289472
- Development and evaluation of albumin binder-conjugated heterodimeric radiopharmaceuticals targeting integrin αvβ3 and CD13 for cancer therapy. | Yang, B., et al. 2024. Eur J Nucl Med Mol Imaging. 51: 3334-3345. PMID: 38787395
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD13 Antibody (WM15) | sc-51522 | 100 µg/ml | $322.00 | |||
CD13 Antibody (WM15) FITC | sc-51522 FITC | 100 tests in 2 ml | $336.00 |