caspase-3 Antibody (CPP324-1-18): sc-56052
- caspase-3 Antibody (CPP324-1-18) is a mouse monoclonal IgG2a κ, cited in 32 publications, provided at 200 µg/ml
- raised against full length caspase-3 of human origin
- Anti-caspase-3 Antibody (CPP324-1-18) is recommended for detection of caspase-3 of mouse, rat and human origin by WB, IP and ELISA
- Anti-caspase-3 Antibody (CPP324-1-18) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for caspase-3 Antibody (CPP324-1-18) for WB applications. These reagents are now offered in bundles with caspase-3 Antibody (CPP324-1-18) (see ordering information below).
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SEE ALSO...
caspase-3 Antibody (CPP324-1-18) is a mouse monoclonal IgG2a kappa light chain antibody engineered to detect the full-length human caspase-3 protein, also known as apopain, SCA-1, Yama, and CPP32. anti-caspase-3 antibody (CPP324-1-18) reliably recognizes caspase-3 across mouse, rat, and human species, and is recommended for use in western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA) applications. Caspase-3 is a critical aspartate-specific cysteine protease within the ICE subfamily, functioning as a key executioner in the apoptosis pathway. Upon activation, caspase-3 interacts with and cleaves several essential proteins, including PARP (poly (ADP-ribose) polymerase), which facilitates the orderly disassembly of cellular components during programmed cell death. Additionally, caspase-3 activates other caspases such as caspase-6, -7, and -9, thereby amplifying the apoptotic signal and ensuring the efficient progression of the apoptotic cascade. Caspase-3 also interacts with SREBPs (sterol regulatory element-binding proteins), regulating lipid metabolism by cleaving and activating these transcription factors. The ability of caspase-3 to interact with multiple proteins underscores its pivotal role in maintaining cellular homeostasis, eliminating damaged or unnecessary cells, and regulating processes like development, immune responses, and cancer prevention. caspase-3 monoclonal antibody (CPP324-1-18) is available in both non-conjugated form and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, offering versatile options for diverse research needs. caspase-3 (CPP324-1-18) antibody is an indispensable tool for scientists studying apoptosis and related cellular mechanisms, making it essential for research in fields such as cancer biology, immunology, and neurodegenerative diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
caspase-3 Antibody (CPP324-1-18) | sc-56052 | 200 µg/ml | $322.00 | |||
caspase-3 Antibody (CPP324-1-18): m-IgG Fc BP-HRP Bundle | sc-525646 | 200 µg Ab; 10 µg BP | $361.00 | |||
caspase-3 Antibody (CPP324-1-18): m-IgG2a BP-HRP Bundle | sc-546353 | 200 µg Ab; 10 µg BP | $361.00 | |||
caspase-3 Antibody (CPP324-1-18) AC | sc-56052 AC | 500 µg/ml, 25% agarose | $424.00 | |||
caspase-3 Antibody (CPP324-1-18) HRP | sc-56052 HRP | 200 µg/ml | $322.00 | |||
caspase-3 Antibody (CPP324-1-18) FITC | sc-56052 FITC | 200 µg/ml | $336.00 | |||
caspase-3 Antibody (CPP324-1-18) PE | sc-56052 PE | 200 µg/ml | $349.00 | |||
caspase-3 Antibody (CPP324-1-18) Alexa Fluor® 488 | sc-56052 AF488 | 200 µg/ml | $364.00 | |||
caspase-3 Antibody (CPP324-1-18) Alexa Fluor® 546 | sc-56052 AF546 | 200 µg/ml | $364.00 | |||
caspase-3 Antibody (CPP324-1-18) Alexa Fluor® 594 | sc-56052 AF594 | 200 µg/ml | $364.00 | |||
caspase-3 Antibody (CPP324-1-18) Alexa Fluor® 647 | sc-56052 AF647 | 200 µg/ml | $364.00 | |||
caspase-3 Antibody (CPP324-1-18) Alexa Fluor® 680 | sc-56052 AF680 | 200 µg/ml | $364.00 | |||
caspase-3 Antibody (CPP324-1-18) Alexa Fluor® 790 | sc-56052 AF790 | 200 µg/ml | $364.00 |