CaMKIV Antibody (B-5): sc-166157

CaMKIV Antibody (B-5) is a mouse monoclonal IgG2b antibody that detects CaMKIV in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). CaMKIV, a member of the calcium/calmodulin-dependent protein kinase family, plays a crucial role in cellular signaling pathways, particularly in the regulation of gene expression and the cell cycle. anti-CaMKIV antibody (B-5) primarily detects nuclear localization, where CaMKIV translocates upon activation by calcium and calmodulin, allowing phosphorylation of specific transcription factors and thereby influencing the expression of genes involved in cell proliferation and differentiation. CaMKIV′s ability to modulate these processes is vital for normal cellular function and has implications in various physiological and pathological conditions, including cancer and neurodegenerative diseases. CaMKIV interacts with other proteins, such as CREB (cAMP response element-binding protein), which further underscores its importance in mediating cellular responses to external stimuli. CaMKIV monoclonal antibody (B-5) serves as an essential tool for researchers exploring the intricate roles of this kinase in human health and disease.

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CaMKIV Antibody (B-5) References:

1. Genetic alteration of anxiety and stress-like behavior in mice lacking CaMKIV.  |  Shum, FW., et al. 2005. Mol Pain. 1: 22. PMID: 16102169
2. Evidence for a role of CaMKIV in the development of opioid analgesic tolerance.  |  Ko, SW., et al. 2006. Eur J Neurosci. 23: 2158-68. PMID: 16630062
3. CaMKII and CaMKIV mediate distinct prosurvival signaling pathways in response to depolarization in neurons.  |  Bok, J., et al. 2007. Mol Cell Neurosci. 36: 13-26. PMID: 17651987
4. Calpain activation and CaMKIV reduction in spinal cords from hSOD1G93A mouse model.  |  Gou-Fabregas, M., et al. 2014. Mol Cell Neurosci. 61: 219-25. PMID: 25063475
5. CaMKIV-dependent preservation of mTOR expression is required for autophagy during lipopolysaccharide-induced inflammation and acute kidney injury.  |  Zhang, X., et al. 2014. J Immunol. 193: 2405-15. PMID: 25070845
6. DJ-1 regulates tyrosine hydroxylase expression through CaMKKβ/CaMKIV/CREB1 pathway in vitro and in vivo.  |  Xu, X., et al. 2020. J Cell Physiol. 235: 869-879. PMID: 31232473
7. In vitro treatment of 3 T3-L1 adipocytes with recombinant Calcium/calmodulin-dependent Protein Kinase IV (CaMKIV) limits ER stress and improves insulin sensitivity through inhibition of autophagy via the mTOR/CREB signaling pathway.  |  Liu, J., et al. 2020. BMC Endocr Disord. 20: 104. PMID: 32660483
8. The Regulating Mechanism of Chrysophanol on Protein Level of CaM-CaMKIV to Protect PC12 Cells Against Aβ25-35-Induced Damage.  |  Ye, T., et al. 2020. Drug Des Devel Ther. 14: 2715-2723. PMID: 32764873
9. Huang-Pu-Tong-Qiao Formula Ameliorates Tau Phosphorylation by Inhibiting the CaM-CaMKIV Pathway.  |  Ye, S., et al. 2020. Evid Based Complement Alternat Med. 2020: 8956071. PMID: 34046075
10. Guilu Erxian Jiao remodels dendritic spine morphology through activation of the hippocampal TRPC6-CaMKIV-CREB signaling pathway and suppresses fear memory generalization in rats with post-traumatic stress disorder.  |  Qu, Y., et al. 2025. J Ethnopharmacol. 340: 119252. PMID: 39681200

The preferred CaMKIV antibody is CaMKIV Antibody (H-5): sc-55501.