ACCÈS RAPIDE AUX LIENS
Milk proteins are crucial for the development of all newborn mammals and caseins constitute the major proteins in mammalian milk. β- and k-caseins are the only caseins present in human milk. The β-casein/k-casein ratio is higher in colostrum than in transitional and mature milk and is related to a better digestibility of colostrum casein micelles by the neonate during the first days of life. Human β-casein-encoding gene (Bca) contains a highly phosphorylated site, which is responsible for the calcium-binding capacity of β-casein. A common set of transcription factors are required for the expression of β-casein. Multiple binding sites for Stat5, C/EBPβ (CCAAT/enhancer-binding protein) and several half-sites for glucocorticoid receptor (GR) are identified in the distal human enhancer of the β-casein gene. β-casein gene transcription is regulated primarily by a composite response element (CoRE), which integrates signaling from the lactogenic hormones PRL, insulin and hydrocortisone in mammary epithelial cells. NFκB functions as a negative regulator of β-casein gene expression during pregnancy by interfering with Stat5 tyrosine phosphorylation.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps β-casein (H-7) | sc-166520 | 200 µg/ml | $316.00 | |||
β-casein (H-7) peptide neutralisant | sc-166520 P | 100 µg/0.5 ml | $68.00 |