Aspartoacylase Antibody (F-1): sc-365588

Aspartoacylase Antibody (F-1) is a mouse monoclonal IgG1 antibody that detects Aspartoacylase in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Aspartoacylase, also referred to as ASPA, ACY2, or ASP, is a 313 amino acid protein predominantly expressed in liver, lung, kidney, skeletal muscle, and cerebral white matter, where ASPA plays a critical role in the central nervous system. ASPA exists as a homodimer and catalyzes the deacetylation of N-acetylaspartic acid (NAA), a process vital for maintaining white matter integrity. The hydrolysis of NAA produces acetate and L-aspartate, which are important for various metabolic pathways. Deficiencies in Aspartoacylase due to genetic mutations lead to Canavan disease, a rare neurodegenerative disorder characterized by severe neurological symptoms, including muscle atonia, hypotonia, and cognitive impairment, ultimately resulting in significant morbidity. Anti-Aspartoacylase antibody (F-1) serves as an invaluable tool for researchers studying Aspartoacylase implications in both normal physiology and disease states, providing insights into functional mechanisms and potential therapeutic targets.

The preferred Aspartoacylase antibody is Aspartoacylase Antibody (D-11): sc-377308.