Anticorps APPL1 (H-3): sc-271909

The APPL family of proteins are involved in linking, trafficking and signaling downstream of tyrosine kinase receptors. APPL1, also designated adaptor protein containing pH domain, PTB domain and leucine zipper motif 1; APPL; or DCC interacting protein 13α (DIP13α), and APPL2, also designated adaptor protein containing pH domain, PTB domain and leucine zipper motif 2 or DCC interacting protein 13β (DIP13β), are involved in the coupling of epidermal growth factor (EGF) signaling and chromatin remodeling in the nucleus. They associate with GTPase Rab 5 and are released from the plasma membrane and translocated to the nucleus. In the nucleus, APPL1 and APPL2 associate with NuRD/MeCP1 and are essential for cell growth and proliferation. APPL1 is also involved in Akt regulation, binding the kinase domains of Akt1 and Akt2; neurotrophin receptor signaling via association with GIPC and Trk A; and it associates with follicle-stimulating hormone receptor (FSHR) and the cata-lytic subunit of type 1A PI 3-kinase. APPL1 is highly expressed in heart, ovary, skeletal muscle and pancreas. APPL1 shares 54% homology with APPL2.

L'anticorps APPL1 préféré est l'Anticorps APPL1 (A-1): sc-271901.