TMEM59 Activateurs
TMEM59," or "Transmembrane Protein 59," is a gene that encodes a protein belonging to the family of transmembrane proteins. As suggested by its name, TMEM59 is characterized by its location within the cellular membrane, indicating a role in cellular processes involving membrane dynamics.TMEM59 is involved in the regulation of endosomal trafficking, a critical process in the cellular transport and sorting of membrane-bound proteins and lipids. Endosomal trafficking is essential for various cellular functions, including signaling, nutrient uptake, and membrane protein recycling or degradation. TMEM59 contributes to the proper functioning of this system by influencing the movement and sorting of endosomal vesicles.
One of the key roles of TMEM59 is in the modulation of the Golgi apparatus, a central organelle in protein and lipid processing and trafficking. TMEM59 has been implicated in Golgi-to-endosome transport, influencing the sorting and delivery of proteins to their appropriate cellular destinations.Research has also highlighted the involvement of TMEM59 in neurodegenerative diseases, particularly in the context of Alzheimer's disease. TMEM59 may affect the processing and trafficking of amyloid precursor protein (APP), a key protein in the pathogenesis of Alzheimer's disease. Alterations in APP processing can lead to the accumulation of amyloid-beta, a hallmark of Alzheimer's pathology.Moreover, TMEM59's role in membrane trafficking and cell signaling pathways suggests its broader relevance in various physiological processes and potentially in other disease mechanisms.
VOIR ÉGALEMENT...
| Nom du produit | CAS # | Ref. Catalogue | Quantité | Prix HT | CITATIONS | Classement |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Régulateur de l'expression génétique, l'acide rétinoïque peut influencer diverses voies de signalisation, ce qui pourrait avoir un impact sur le TMEM59. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Un inhibiteur de la pompe à protons V-ATPase, affectant l'acidification lysosomale et influençant potentiellement le rôle de TMEM59 dans le tri lysosomal. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Connue pour affecter la fonction lysosomale, la chloroquine peut avoir un impact indirect sur l'activité du TMEM59 liée au tri lysosomal. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Inhibiteur de GSK-3, affectant la signalisation Wnt et ayant un impact potentiel sur la fonction TMEM59. | ||||||
FCM Lysing solution (1x) | sc-3621 | 150 ml | $61.00 | 8 | ||
Un agent lysosomotrope qui peut augmenter le pH lysosomal, influençant potentiellement le rôle du TMEM59 dans la fonction lysosomale. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Inhibiteur de mTOR, influençant l'autophagie et la fonction lysosomale, ayant un impact potentiel sur le TMEM59. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Inhibiteur de la glycosylation liée à l'azote, affectant le trafic des protéines et potentiellement la fonction du TMEM59. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Agent dépolymérisant les microtubules, affectant le transport intracellulaire, influençant potentiellement le TMEM59. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $94.00 $286.00 | 27 | |
En tant qu'inhibiteur de la production de Wnt, l'IWP-2 peut avoir un impact indirect sur la fonction du TMEM59 dans les voies de signalisation Wnt. | ||||||