myotubularin Activators
Myotubularin Activators are a class of compounds that influence the cellular and biochemical contexts within which myotubularin operates. Since myotubularin is a lipid phosphatase that specifically dephosphorylates PI3P, the upstream regulation of PI3P levels is a critical determinant of myotubularin activity. Compounds like Wortmannin and LY294002, which are PI3K inhibitors, the conversion of PI3P to more phosphorylated forms such as PI(3,4)P2. This results in an accumulation of PI3P, myotubularin's substrate, potentially leading to enhanced dephosphorylation activity by myotubularin. Similarly, Perifosine, by inhibiting Akt, may indirectly lead to increased PIMyotubularin Activators are a class of compounds that influence the cellular and biochemical contexts within which myotubularin operates.
Other compounds that influence the myotubularin activity include those that affect the autophagy pathway, such as 3-Methyladenine, which inhibits class III PI3K Vps34, leading to potentially higher levels of PI3P and thus enhancing the function of myotubularin. Rapamycin, by inhibiting mTOR, can also cause a feedback upregulation of the PI3K pathway, increasing the levels of PI3P and potentially enhancing myotubularin's activity. Additionally, lipid modulators like Sphingosine and Ceramide can influence membrane dynamics and indirectly affect PI3K pathway signaling, which could lead to alterations in PI3P levels and modulation of myotubularin activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Another PI3K inhibitor that prevents the conversion of PI3P to PI(3,4)P2, similarly leading to increased PI3P levels, which myotubularin can act upon, potentially enhancing its function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
A MEK inhibitor that may lead to altered cellular signaling dynamics, potentially affecting the cross-talk with PI3K pathway and indirectly influencing the activity of myotubularin. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A p38 MAPK inhibitor that could modify cellular responses to stress and inflammation, potentially affecting the PI3K pathway and indirectly enhancing myotubularin activity by altering PI3P levels. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor that can lead to feedback upregulation of the PI3K pathway, potentially increasing PI3P levels and indirectly enhancing myotubularin's phosphatase activity. | ||||||
ZSTK 474 | 475110-96-4 | sc-475495 | 5 mg | $75.00 | ||
A PI3K inhibitor that could cause an accumulation of PI3P, indirectly enhancing the functional activity of myotubularin by increasing the levels of its substrate. | ||||||
PI-103 | 371935-74-9 | sc-203193 sc-203193A | 1 mg 5 mg | $33.00 $131.00 | 3 | |
A dual PI3K/mTOR inhibitor that can lead to increased PI3P levels by inhibiting its downstream phosphorylation, potentially enhancing the activity of myotubularin. | ||||||
D-erythro-Sphingosine | 123-78-4 | sc-3546 sc-3546A sc-3546B sc-3546C sc-3546D sc-3546E | 10 mg 25 mg 100 mg 1 g 5 g 10 g | $90.00 $194.00 $510.00 $2448.00 $9384.00 $15300.00 | 2 | |
A bioactive lipid that can modulate sphingolipid signaling pathways, potentially influencing the PI3K pathway and indirectly enhancing the activity of myotubularin through changes in membrane lipid composition. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
A PPAR-alpha agonist that modulates lipid metabolism, which may indirectly influence the PI3K pathway and enhance myotubularin activity by affecting membrane lipid composition and PI3P levels. | ||||||
C2 Ceramide | 3102-57-6 | sc-201375 sc-201375A | 5 mg 25 mg | $124.00 $460.00 | 12 | |
A sphingolipid that can alter cell membrane properties and influence signaling pathways, potentially increasing PI3P levels and indirectly enhancing the functional activity of myotubularin. | ||||||