Gar22 Activateurs
Growth Arrest Specific 2 Like 1, commonly abbreviated as GAS2L1, is a member of the GAS2 family of proteins which are known for their role in the regulation of the cell cycle and cytoskeleton organization. This evolutionarily conserved protein family is characterized by the presence of a Gas2-related domain that interacts with microtubules and is implicated in the coordination of cell proliferation and apoptosis.
GAS2L1 itself is particularly interesting due to its involvement in the stabilization of the microtubule network as well as its role in cytokinesis, the final step of cell division where the cell splits into two daughter cells. The protein is thought to localize to the spindle apparatus during mitosis, and its activity is crucial for the proper alignment and segregation of chromosomes.
The structure of GAS2L1 includes a calponin homology (CH) domain that mediates binding to actin filaments, and a Gas2 domain that is associated with microtubule plus-end tracking (+TIPs). This allows GAS2L1 to act as a cross-linker between actin filaments and microtubules, a function that is essential for maintaining the integrity and dynamics of the cytoskeleton. Furthermore, GAS2L1 may also be involved in cellular processes that require cytoskeletal remodeling, such as cell migration and adhesion.Research has shown that GAS2L1 can be regulated by various cellular signals and may be subject to post-translational modifications that alter its function. Aberrations in the expression or function of GAS2L1 have been suggested to play a role in certain pathological conditions, including cancer, where it may affect tumor cell growth and metastasis.
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| Nom du produit | CAS # | Ref. Catalogue | Quantité | Prix HT | CITATIONS | Classement |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
La forskoline active l'adénylyl cyclase, augmentant les niveaux d'AMPc, ce qui peut renforcer l'activité de la PKA et potentiellement augmenter la régulation de GAS2L1. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
L'acide rétinoïque module l'expression des gènes par l'intermédiaire des récepteurs de l'acide rétinoïque, ce qui pourrait inclure l'activation transcriptionnelle de GAS2L1. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
La trichostatine A inhibe les histones désacétylases, ce qui conduit à un état chromatinien plus détendu, augmentant probablement l'expression de GAS2L1. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
La 5-azacytidine inhibe les ADN méthyltransférases, ce qui pourrait déméthyler le promoteur de GAS2L1 et en augmenter l'expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Le resvératrol active SIRT1, ce qui peut conduire à la désacétylation des facteurs de transcription qui régulent l'expression de GAS2L1. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
La PMA active la protéine kinase C (PKC) qui pourrait moduler les facteurs de transcription impliqués dans l'expression de GAS2L1. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Le butyrate de sodium est un inhibiteur de l'histone désacétylase, qui pourrait augmenter l'acétylation et donc l'expression de GAS2L1. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
L'EGCG inhibe les ADN méthyltransférases, ce qui peut entraîner une hypométhylation et une activation de l'expression du gène GAS2L1. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Le chlorure de lithium inhibe GSK-3β, influençant potentiellement la signalisation Wnt et régulant les facteurs de transcription pour GAS2L1. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
La rapamycine inhibe mTOR, ce qui peut entraîner une augmentation compensatoire des protéines liées à l'autophagie, y compris GAS2L1. | ||||||