CPI-17 Activateurs

Les activateurs CPI-17 courants comprennent, entre autres, le PMA CAS 16561-29-8, la rottlerine CAS 82-08-6, la caliculine A CAS 101932-71-2, l'acide okadaïque CAS 78111-17-8 et la ruboxistaurine CAS 169939-94-0.

CPI-17 activators are a class of chemical compounds with the unique ability to interact with and modulate the activity of protein kinase C-potentiated myosin phosphatase inhibitor 1 (CPI-17). CPI-17 is a regulatory protein involved in the modulation of smooth muscle contraction, and plays an essential role in the regulation of various physiological processes, particularly in the smooth muscle tissues of the cardiovascular and gastrointestinal systems. CPI-17 activators are compounds that can influence CPI-17 activation, phosphorylation or interactions, thereby impacting smooth muscle tone, contractility and other cellular processes associated with the regulation of muscle function.

The mechanism of action of CPI-17 activators generally involves their ability to modulate the phosphorylation state of CPI-17. CPI-17 functions as an inhibitor of myosin phosphatase, a key enzyme responsible for the dephosphorylation of myosin light chain (MLC) in smooth muscle cells. When CPI-17 is phosphorylated, it becomes active and inhibits myosin phosphatase, resulting in increased levels of phosphorylated MLC and enhanced smooth muscle contraction. Activators can increase or inhibit IPC-17 phosphorylation, thus affecting its activity and ability to modulate smooth muscle contractility. In addition, they may influence the interactions of CPI-17 with other regulatory or scaffolding proteins, which may further regulate its function in smooth muscle tissue. Understanding the properties and effects of CPI-17 activators is important in the field of smooth muscle physiology and contractility, as it enhances our understanding of the molecular mechanisms that govern muscle tone and contraction, which are essential for various physiological processes such as blood vessel constriction and gastrointestinal motility. It contributes to our understanding of how specific compounds can modulate muscle function and influence the regulation of smooth muscle contractility.