VCAM-1 Antibody (MR106): sc-53548

VCAM-1 Antibody (MR106) is a mouse monoclonal IgG1 kappa light chain antibody raised against rat VCAM-1 from transfected L5178Y cells of rat origin, and specifically reacts with rat VCAM-1. Vascular Cell Adhesion Molecule 1 (VCAM-1), also known as CD106, is a transmembrane glycoprotein expressed on activated endothelial cells. VCAM-1 plays a crucial role in mediating the adhesion and transmigration of leukocytes across the endothelium during immune responses. VCAM-1 interacts with integrins such as VLA-4 (α4β1 integrin) on leukocytes, facilitating their movement into tissues at sites of inflammation. This function is important for immune surveillance and contributes to the pathogenesis of various inflammatory diseases when dysregulated. VCAM-1 expression is upregulated by inflammatory cytokines like interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-α), and lipopolysaccharide (LPS). Understanding VCAM-1′s role is essential for researching conditions such as atherosclerosis, rheumatoid arthritis, and other inflammatory disorders. Anti-VCAM-1 antibody (MR106) is suitable for applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM), making VCAM-1 (MR106) monoclonal antibody a valuable tool for studying VCAM-1 function and involvement in immune cell trafficking. By targeting VCAM-1, researchers can investigate VCAM-1′s role in leukocyte adhesion and transmigration, contributing to the development of therapeutic strategies against diseases involving abnormal immune responses.

The preferred VCAM-1 antibody is VCAM-1 Antibody (E-10): sc-13160.