STRAP Antibody (3G6): sc-130671

STRAP Antibody (3G6) is a mouse monoclonal IgG1 antibody that detects STRAP in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). STRAP, or the unr-interacting protein, plays a crucial role in the regulation of the TGFβ signaling pathway, acting as an antagonist to TGFβ-induced transcriptional activation. STRAP specifically interacts with Smad7, enhancing the inhibition of TGFβ signaling, which is vital for maintaining cellular homeostasis and preventing excessive cellular responses that could lead to pathological conditions. The STRAP gene is located on chromosome 12p12.3 in humans and exhibits a remarkable 97% amino acid homology with its mouse counterpart, underscoring its evolutionary conservation across species. STRAP′s interaction with unr, a cytoplasmic RNA-binding protein, highlights its involvement in RNA translation, further emphasizing its importance in cellular processes. STRAP′s ability to modulate TGFβ signaling pathways makes STRAP a significant target for research in various diseases, including fibrosis and cancer, where TGFβ signaling is often dysregulated. Anti-STRAP antibody (3G6) is an essential tool for researchers aiming to explore the intricate mechanisms of TGFβ signaling and its implications in health and disease.

The preferred STRAP antibody is STRAP Antibody (E-8): sc-377345.