serum reponse factor /SRF Antibody (SRF01 [SR28]): sc-56779

SRF Antibody (SRF01 [SR28]) is a mouse monoclonal IgG1 antibody that detects serum response factor (SRF) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). SRF is a crucial transcription factor that binds to the serum response element (SRE), playing a significant role in mediating the cellular response to growth stimulation by regulating the expression of various genes. The importance of SRF extends to its involvement in muscle-specific gene expression, where SRF acts as a constitutive promoter element in many muscle-specific promoters. Notably, SRF forms a ternary complex with accessory proteins, such as p62TCF, which is essential for effective signal transduction at the c-Fos SRE. Additionally, SRF interacts with related Ets domain proteins, including Elk-1 and SRF accessory protein-1 (SAP-1), which share similar DNA binding properties and contribute to the formation of this complex. The structural integrity of SRF and its interacting partners allows for the precise regulation of gene expression in response to extracellular signals, ultimately influencing cellular growth and differentiation. Anti-SRF antibody (SRF01 [SR28]) serves as an invaluable tool for researchers studying the molecular mechanisms underlying cellular responses to growth factors and the regulation of muscle-specific gene expression.

The preferred serum reponse factor /SRF antibody is serum reponse factor /SRF Antibody (A-11): sc-25290.