SRF Inhibitors
Common SRF Inhibitors include, but are not limited to CCG-1423 CAS 285986-88-1, (±)-Blebbistatin CAS 674289-55-5, Y-27632, free base CAS 146986-50-7, Sanguinarium CAS 2447-54-3 and CC-401 CAS 395104-30-0.
SRF inhibitors belong to a specific chemical class of compounds designed to target and inhibit the activity of Serum Response Factor (SRF). SRF is a transcription factor that plays a crucial role in the regulation of gene expression in response to various extracellular signals. It is involved in controlling the expression of genes that are important for cell growth, migration, and differentiation. SRF is activated by binding to its coactivator, myocardin-related transcription factors (MRTFs), in response to changes in the cellular environment.
SRF inhibitors work by specifically targeting the SRF protein or its interaction with MRTFs, interfering with its ability to bind to DNA and regulate the expression of target genes. By doing so, these inhibitors may modulate cellular responses to extracellular signals and affect various cellular processes that are regulated by SRF-mediated gene expression. Research into SRF and its inhibitors is ongoing to unravel their precise mechanisms of action and explore their implications in cellular signaling. The study of SRF inhibitors represents an intriguing area of research, contributing to a deeper understanding of the intricate mechanisms governing gene expression and cellular responses to external stimuli.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
CCG-1423 | 285986-88-1 | sc-205241 sc-205241A | 1 mg 5 mg | $30.00 $90.00 | 8 | |
Inhibits the interaction between SRF and its co-activator MKL1, preventing the formation of the transcriptional complex, and downregulating SRF-dependent gene expression. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $179.00 $307.00 $455.00 $924.00 $1689.00 | 7 | |
Suppresses SRF activity by disrupting the actin-myosin interaction, leading to reduced cytoskeletal dynamics and cell motility in a variety of cell types. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Inhibits Rho-associated protein kinases (ROCK), preventing their activation of SRF and reducing smooth muscle cell contraction and fibrosis. | ||||||
CCG 203971 | 1443437-74-8 | sc-507360 | 10 mg | $89.00 | ||
Blocks SRF transcriptional activity by disrupting its binding to DNA, leading to downregulation of SRF-dependent gene expression and cellular responses. | ||||||
Sanguinarium | 2447-54-3 | sc-473396 | 10 mg | $220.00 | ||
Inhibits SRF nuclear translocation and its binding to target genes, reducing the expression of SRF-regulated genes involved in cell proliferation and migration. | ||||||
CC-401 | 395104-30-0 | sc-364748 sc-364748A | 2 mg 10 mg | $331.00 $1060.00 | 4 | |
Inhibits the activity of the SRF-cofactor complex (SRF/MKL1), leading to decreased SRF-dependent gene expression and potential antitumor effects in glioblastoma. | ||||||
Fursultiamine | 804-30-8 | sc-495854 sc-495854A | 25 mg 100 mg | $265.00 $622.00 | 1 | |
Acts as a potent and selective SRF inhibitor, disrupting its DNA-binding activity, leading to downregulation of SRF-dependent gene expression and inhibition of cell growth. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
Inhibits myosin light chain kinase (MLCK), reducing the phosphorylation of myosin and SRF activity, and affecting smooth muscle cell contractility and migration. | ||||||
Gallotannin | 1401-55-4 | sc-202619 sc-202619A sc-202619B sc-202619C sc-202619D sc-202619E sc-202619F | 1 g 10 g 100 g 250 g 1 kg 2.5 kg 5 kg | $25.00 $36.00 $66.00 $76.00 $229.00 $525.00 $964.00 | 12 | |
Inhibits SRF binding to DNA, preventing the activation of SRF-dependent gene expression and altering cellular responses in a variety of biological contexts. | ||||||