spectrin β II Antibody (F-11): sc-376487
- spectrin β II Antibody (F-11) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 2086-2210 mapping near the C-terminus of spectrin β II of human origin
- recommended for detection of spectrin β II of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including canine
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for spectrin β II Antibody (F-11) for WB and IHC(P) applications. These reagents are now offered in bundles with spectrin β II Antibody (F-11) (see ordering information below).
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SEE ALSO...
spectrin β II Antibody (F-11) is a mouse monoclonal IgG1 antibody that detects spectrin β II in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Spectrin β II plays a crucial role in maintaining the structural integrity and organization of the cytoskeleton, particularly in non-erythroid cells, where spectrin β II contributes to the dynamic organization of the plasma membrane and facilitates cellular processes such as secretion. Spectrin β II interacts with calmodulin in a calcium-dependent manner, which is essential for the regulation of cytoskeletal movement at the membrane, highlighting spectrin β II′s importance in cellular signaling and function. The human SPTBN1 gene encodes the nonerythroid form of β-spectrin, and spectrin β II′s proper functioning is vital for various cellular activities, including maintaining cell shape and enabling cellular communication. Anti-spectrin β II antibody (F-11) is an invaluable tool for researchers studying cytoskeletal dynamics and related cellular processes across different species.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
spectrin β II Antibody (F-11) References:
- Polarized expression of immunoglobulin, spectrin, and protein kinase C beta II occurs in B cells from normal BALB/c, autoimmune lpr, and anti-ssDNA transgenic, tolerant mice. | Masso-Welch, PA., et al. 1999. J Leukoc Biol. 66: 617-24. PMID: 10534118
- A constitutively active SPTBN1-FLT3 fusion in atypical chronic myeloid leukemia is sensitive to tyrosine kinase inhibitors and immunotherapy. | Grand, FH., et al. 2007. Exp Hematol. 35: 1723-7. PMID: 17764812
- Fusion of PRKG2 and SPTBN1 to the platelet-derived growth factor receptor beta gene (PDGFRB) in imatinib-responsive atypical myeloproliferative disorders. | Gallagher, G., et al. 2008. Cancer Genet Cytogenet. 181: 46-51. PMID: 18262053
- Lung adenocarcinoma harboring concomitant SPTBN1-ALK fusion, c-Met overexpression, and HER-2 amplification with inherent resistance to crizotinib, chemotherapy, and radiotherapy. | Gu, FF., et al. 2016. J Hematol Oncol. 9: 66. PMID: 27496196
- Gene-gene and gene-lifestyle interactions of AKAP11, KCNMA1, PUM1, SPTBN1, and EPDR1 on osteoporosis risk in middle-aged adults. | Park, S., et al. 2020. Nutrition. 79-80: 110859. PMID: 32619791
- SPTBN1 inhibits inflammatory responses and hepatocarcinogenesis via the stabilization of SOCS1 and downregulation of p65 in hepatocellular carcinoma. | Lin, L., et al. 2021. Theranostics. 11: 4232-4250. PMID: 33754058
- Heterozygous variants in SPTBN1 cause intellectual disability and autism. | Rosenfeld, JA., et al. 2021. Am J Med Genet A. 185: 2037-2045. PMID: 33847457
- Pathogenic SPTBN1 variants cause an autosomal dominant neurodevelopmental syndrome. | Cousin, MA., et al. 2021. Nat Genet. 53: 1006-1021. PMID: 34211179
- Identification of bone mineral density associated genes with shared genetic architectures across multiple tissues: Functional insights for EPDR1, PKDCC, and SPTBN1. | Jung, J. and Wu, Q. 2024. PLoS One. 19: e0300535. PMID: 38683846
- Definition of a sequence unique in beta II spectrin required for its axon-specific interaction with fodaxin (A60). | Hayes, NV., et al. 1997. J Neurochem. 68: 1686-95. PMID: 9084442
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
spectrin β II Antibody (F-11) | sc-376487 | 200 µg/ml | $322.00 | |||
spectrin β II Antibody (F-11): m-IgG Fc BP-HRP Bundle | sc-540583 | 200 µg Ab; 10 µg BP | $361.00 | |||
spectrin β II Antibody (F-11): m-IgG1 BP-HRP Bundle | sc-542221 | 200 µg Ab; 20 µg BP | $361.00 |