SH-PTP1 Antibody (PTY6): sc-52885
- SH-PTP1 Antibody (PTY6) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant full length SH-PTP1 of human origin
- recommended for detection of SH-PTP1 of human origin by WB, IP, IF and ELISA
- See SH-PTP1 (D-11): sc-7289 for SH-PTP1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SH-PTP1 Antibody (PTY6). This work is in progress.
SH-PTP1 Antibody (PTY6) is a mouse monoclonal IgG1 antibody that detects SH-PTP1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SH-PTP1, also known as PTP1C, HCP, and SHP, plays a crucial role in regulating protein tyrosyl phosphorylation within cells, a process vital for various cellular functions, including signal transduction and cell growth. SH-PTP1 is primarily expressed in hematopoietic cells and is characterized by two SH2 domains located N-terminal to its phosphatase domain. These SH2 domains are essential for mediating SH-PTP1 interaction with specific phosphotyrosine-containing sites on autophosphorylated receptors, thereby influencing initial engagement of these receptors with their substrates. SH-PTP1′s ability to modulate signaling pathways highlights its importance in maintaining cellular homeostasis and potential implications in hematological disorders. Anti-SH-PTP1 antibody (PTY6) serves as an invaluable tool for researchers investigating the intricate mechanisms of tyrosine phosphorylation and its impact on cellular behavior.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SH-PTP1 Antibody (PTY6) References:
- Vascular endothelial growth factor-induced endothelial cell proliferation is regulated by interaction between VEGFR-2, SH-PTP1 and eNOS. | Cai, J., et al. 2006. Microvasc Res. 71: 20-31. PMID: 16337972
- Valproic acid increases NO production via the SH-PTP1-CDK5-eNOS-Ser(116) signaling cascade in endothelial cells and mice. | Cho, DH., et al. 2014. Free Radic Biol Med. 76: 96-106. PMID: 25150199
- Translocation of an SH2-containing protein tyrosine phosphatase (SH-PTP1) to the cytoskeleton of thrombin-activated platelets. | Li, RY., et al. 1994. FEBS Lett. 343: 89-93. PMID: 7512933
- Intramolecular regulation of protein tyrosine phosphatase SH-PTP1: a new function for Src homology 2 domains. | Pei, D., et al. 1994. Biochemistry. 33: 15483-93. PMID: 7528537
- Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. | Klingmüller, U., et al. 1995. Cell. 80: 729-38. PMID: 7889566
- Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells. | Lorenz, U., et al. 1994. Mol Cell Biol. 14: 1824-34. PMID: 8114715
- Differential functions of the two Src homology 2 domains in protein tyrosine phosphatase SH-PTP1. | Pei, D., et al. 1996. Proc Natl Acad Sci U S A. 93: 1141-5. PMID: 8577729
- G-protein beta gamma subunits mediate specific phosphorylation of the protein-tyrosine phosphatase SH-PTP1 induced by lysophosphatidic acid. | Gaits, F., et al. 1996. J Biol Chem. 271: 20151-5. PMID: 8798377
- Alterations in activity of protein tyrosine phosphatase SH-PTP1 in autoimmune MRL/mpj-lpr/lpr mice. | Matsuda, A., et al. 1996. J Biochem. 119: 329-33. PMID: 8882726
- Localization of SH-PTP1 to synaptic vesicles: a possible role in neurotransmission. | Jena, BP., et al. 1997. Cell Biol Int. 21: 469-76. PMID: 9451803
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SH-PTP1 Antibody (PTY6) | sc-52885 | 100 µg/ml | $322.00 |