secretin Antibody (E-9): sc-166112
- secretin Antibody (E-9) is a mouse monoclonal IgG1 κ secretin antibody provided at 200 µg/ml
- raised against amino acids 33-121 mapping within an N-terminal extracellular domain of secretin of human origin
- secretin Antibody (E-9) is recommended for detection of secretin of human origin by WB, IP, IF and ELISA
- Anti-secretin Antibody (E-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for secretin Antibody (E-9) for WB applications. These reagents are now offered in bundles with secretin Antibody (E-9) (see ordering information below).
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secretin Antibody (E-9) is an IgG1 κ mouse monoclonal secretin antibody (also designated secretin antibody) that detects the secretin protein of human origin by WB, IP, IF and ELISA. secretin Antibody (E-9) is available as both the non-conjugated anti-secretin receptor antibody form, as well as multiple conjugated forms of anti-secretin receptor antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Secretin is a 27-amino acid hormone produced by specific endocrine cells, S cells, located in the mucosa of the proximal small intestine. Secretin is known to be a potent stimulus for the secretion of bicarbonate-rich pancreatic juice. Secretion of secretin is stimulated by the presence of either acidic pH or fatty acids in the duodenum. Secretin is synthesized as a larger precursor. The deduced amino acid sequence includes a signal peptide, an amino-terminal peptide, secretin itself, and a 72-amino acid carboxy-terminal peptide. Secretin stimulates ductal bile secretion by directly interacting with cholangiocytes. It stimulates exocytosis in cholangiocytes, which transport water mainly via the water channel aquaporin-1. Secretin deficiency may be implicated in autistic syndrome, suggesting that the hormone could have a neuroendocrine function in addition to its role in digestion. The gene which encodes secretin maps to human chromosome 11p15.5.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
secretin Antibody (E-9) References:
- Human secretin (SCT): gene structure, chromosome location, and distribution of mRNA. | Whitmore, TE., et al. 2000. Cytogenet Cell Genet. 90: 47-52. PMID: 11060443
- The mechanism of pancreatic secretion. | Bayliss, WM. and Starling, EH. 1902. J Physiol. 28: 325-53. PMID: 16992627
- Secretin: structure of the precursor and tissue distribution of the mRNA. | Kopin, AS., et al. 1990. Proc Natl Acad Sci U S A. 87: 2299-303. PMID: 2315322
- Structure of porcine secretin. The amino acid sequence. | Mutt, V., et al. 1970. Eur J Biochem. 15: 513-9. PMID: 5465996
- Secretin promotes osmotic water transport in rat cholangiocytes by increasing aquaporin-1 water channels in plasma membrane. Evidence for a secretin-induced vesicular translocation of aquaporin-1. | Marinelli, RA., et al. 1997. J Biol Chem. 272: 12984-8. PMID: 9148905
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
secretin Antibody (E-9) | sc-166112 | 200 µg/ml | $322.00 | |||
secretin Antibody (E-9): m-IgG Fc BP-HRP Bundle | sc-527138 | 200 µg Ab; 10 µg BP | $361.00 | |||
secretin Antibody (E-9): m-IgG1 BP-HRP Bundle | sc-532511 | 200 µg Ab; 20 µg BP | $361.00 | |||
secretin Antibody (E-9) AC | sc-166112 AC | 500 µg/ml, 25% agarose | $424.00 | |||
secretin Antibody (E-9) HRP | sc-166112 HRP | 200 µg/ml | $322.00 | |||
secretin Antibody (E-9) FITC | sc-166112 FITC | 200 µg/ml | $336.00 | |||
secretin Antibody (E-9) PE | sc-166112 PE | 200 µg/ml | $349.00 | |||
secretin Antibody (E-9) Alexa Fluor® 488 | sc-166112 AF488 | 200 µg/ml | $364.00 | |||
secretin Antibody (E-9) Alexa Fluor® 546 | sc-166112 AF546 | 200 µg/ml | $364.00 | |||
secretin Antibody (E-9) Alexa Fluor® 594 | sc-166112 AF594 | 200 µg/ml | $364.00 | |||
secretin Antibody (E-9) Alexa Fluor® 647 | sc-166112 AF647 | 200 µg/ml | $364.00 | |||
secretin Antibody (E-9) Alexa Fluor® 680 | sc-166112 AF680 | 200 µg/ml | $364.00 | |||
secretin Antibody (E-9) Alexa Fluor® 790 | sc-166112 AF790 | 200 µg/ml | $364.00 |