p53CSV Antibody (A-11): sc-515811

p53CSV Antibody (A-11) is a mouse monoclonal IgG1 antibody that detects p53CSV in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p53CSV, also known as WF-1, HSPC132, or TRIAP1 (TP53 regulated inhibitor of apoptosis 1), is a 76 amino acid protein that plays a crucial role in cellular response to stress by localizing to the cytoplasm and perinuclear region of cells. p53CSV is essential for mediating cell survival, as p53CSV inhibits the activation of caspase-9, thereby preventing the induction of apoptosis. Notably, p53CSV is significantly induced under conditions of low genotoxic stress, which is vital for maintaining cell viability during mild stress, while p53CSV expression does not increase in response to severe DNA damage. The interaction between p53CSV and HSP 70 is particularly important, as this interaction may modulate the apoptotic pathway and inhibit the activity of Apaf-1 (apoptosis protease activating factor-1), further underscoring p53CSV′s role in regulating apoptosis. Regulated by the tumor suppressor protein p53, p53CSV is encoded by a gene located on human chromosome 12, which is home to over 1,100 genes and constitutes approximately 4.5% of the human genome, highlighting p53CSV′s significance in cellular processes and potential implications in cancer biology. anti-p53CSV antibody (A-11) is an invaluable tool for researchers investigating the mechanisms of apoptosis and cell survival in various biological contexts.

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p53CSV Antibody (A-11) References:

1. The p53 tumor suppressor network is a key responder to microenvironmental components of chronic inflammatory stress.  |  Staib, F., et al. 2005. Cancer Res. 65: 10255-64. PMID: 16288013
2. High TRIAP1 expression in penile carcinoma is associated with high risk of recurrence and poor survival.  |  Zhang, J., et al. 2019. Ann Transl Med. 7: 330. PMID: 31475200
3. TRIAP1 Inhibition Activates the Cytochrome c/Apaf-1/Caspase-9 Signaling Pathway to Enhance Human Ovarian Cancer Sensitivity to Cisplatin.  |  Zhang, TM. 2019. Chemotherapy. 64: 119-128. PMID: 31661694
4. TRIAP1 knockdown sensitizes non-small cell lung cancer to ionizing radiation by disrupting redox homeostasis.  |  Hao, CC., et al. 2020. Thorac Cancer. 11: 1015-1025. PMID: 32096592
5. Upregulation of TRIAP1 by the lncRNA MFI2-AS1/miR-125a-5p Axis Promotes Thyroid Cancer Tumorigenesis.  |  Yu, T., et al. 2020. Onco Targets Ther. 13: 6967-6974. PMID: 32764987
6. Abnormal expression of TRIAP1 and its role in gestational diabetes mellitus-related pancreatic β cells.  |  Li, L., et al. 2021. Exp Ther Med. 21: 187. PMID: 33488796
7. Relevance of the TRIAP1/p53 axis in colon cancer cell proliferation and adaptation to glutamine deprivation.  |  Nedara, K., et al. 2022. Front Oncol. 12: 958155. PMID: 36387192
8. CHCHD4-TRIAP1 regulation of innate immune signaling mediates skeletal muscle adaptation to exercise.  |  Ma, J., et al. 2024. Cell Rep. 43: 113626. PMID: 38157298
9. Correlation of C-type virus (WF-1) production and heme synthesis in a rat fibroblastic cell line.  |  Ebert, PS. and Pearson, GR. 1974. Proc Soc Exp Biol Med. 145: 298-301. PMID: 4360116
10. Biochemical characteristics of rat C-type virus WF-1.  |  Bronson, DL., et al. 1976. Proc Soc Exp Biol Med. 152: 116-21. PMID: 57624

The preferred p53CSV antibody is p53CSV Antibody (B-12): sc-515801.