Nischarin Antibody (B-3): sc-365364
- Nischarin Antibody (B-3) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 539-567 within an internal region of Nischarin of human origin
- recommended for detection of Nischarin of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Nischarin Antibody (B-3) for WB applications. These reagents are now offered in bundles with Nischarin Antibody (B-3) (see ordering information below).
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Nischarin Antibody (B-3) is a mouse monoclonal IgG1 antibody that detects Nischarin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Nischarin is a novel intracellular protein that plays a crucial role in regulating cell migration by interacting with integrin α5/β1 and various members of the PAK family of kinases. Specifically, anti-Nischarin antibody (B-3) binds to PAK1, inhibiting its ability to phosphorylate substrates, which is vital for controlling cellular signaling pathways that govern motility and cytoskeletal dynamics. Nischarin localizes primarily in the cytoplasm, particularly in the kidney and brain, underscoring its importance in cellular functions and signaling within these tissues. By modulating the activity of Rac and influencing actin filament organization, Nischarin contributes to the intricate balance of cell movement and stability, making Nischarin a significant player in processes such as wound healing and tissue remodeling. Nischarin (B-3) antibody′s versatility in various applications allows researchers to explore Nischarin′s role in different biological contexts, enhancing our understanding of its function in health and disease.
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Nischarin Antibody (B-3) References:
- Nischarin is differentially expressed in rat brain and regulates neuronal migration. | Ding, Y., et al. 2013. PLoS One. 8: e54563. PMID: 23342172
- Inhibition of Nischarin Expression Promotes Neurite Outgrowth through Regulation of PAK Activity. | Ding, Y., et al. 2015. PLoS One. 10: e0144948. PMID: 26670864
- Nischarin regulates focal adhesion and Invadopodia formation in breast cancer cells. | Maziveyi, M., et al. 2018. Mol Cancer. 17: 21. PMID: 29415725
- Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth. | Maziveyi, M., et al. 2019. Cancer Res. 79: 2152-2166. PMID: 30635277
- Nischarin Regulates Secretion of Exosomes and Cancer Progression. | McAndrews, KM. and Kalluri, R. 2019. Cancer Res. 79: 2099-2101. PMID: 31043427
- Impact of Nischarin on EMT regulators in breast cancer cell lines. | Cai, YJ., et al. 2020. Oncol Lett. 20: 291. PMID: 33101485
- Role of Nischarin in the pathology of diseases: a special emphasis on breast cancer. | Okpechi, SC., et al. 2022. Oncogene. 41: 1079-1086. PMID: 35064214
- Nischarin Is Not the Functional I1 Imidazoline Receptor Involved in Blood Pressure Regulation. | Arnoux, A., et al. 2022. J Cardiovasc Pharmacol. 79: 229-234. PMID: 35485584
- Contribution of Nischarin/IRAS in CNS development, injury and diseases. | Zheng, P., et al. 2023. J Adv Res. 54: 43-57. PMID: 36716956
- Nischarin expression may have differing roles in male and female melanoma patients. | Ostojić, M., et al. 2023. J Mol Med (Berl). 101: 1001-1014. PMID: 37382661
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nischarin Antibody (B-3) | sc-365364 | 200 µg/ml | $322.00 | |||
Nischarin Antibody (B-3): m-IgG Fc BP-HRP Bundle | sc-540331 | 200 µg Ab; 10 µg BP | $361.00 | |||
Nischarin Antibody (B-3): m-IgG1 BP-HRP Bundle | sc-542047 | 200 µg Ab; 20 µg BP | $361.00 | |||
Nischarin (B-3) Neutralizing Peptide | sc-365364 P | 100 µg/0.5 ml | $69.00 |