NCAM/CD56 Antibody (2Q692): sc-71647

NCAM Antibody (2Q692) is a mouse monoclonal IgG1 kappa light chain antibody specifically engineered to recognize the human Neural Cell Adhesion Molecule (NCAM), also known as CD56 or NCAM1. NCAM is a vital cell surface glycoprotein located on the plasma membrane, where it facilitates crucial cell-to-cell interactions essential for neural development, synaptic plasticity, and the maintenance of neural networks. This strategic localization on the cell surface enables NCAM to mediate interactions between neurons, playing a pivotal role in embryogenesis and the formation of the nervous system. anti-NCAM antibody (C5.9) detects human NCAM through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM), though does not cross-react with mouse NCAM. NCAM (C5.9) antibody makes an invaluable tool for studying NCAM′s involvement in both normal physiological functions and pathological conditions. NCAM expression is prominently observed in several human tumors, including neuroblastomas, rhabdomyosarcomas, Wilms′ tumor, Ewing′s sarcoma, and certain primitive myeloid malignancies, making NCAM monoclonal antibody (C5.9) recommended for cancer research and diagnostics. anti-NCAM antibody (C5.9) assists researchers in elucidating the mechanisms underlying cell adhesion, neural network formation, and the progression of various neuro-related cancers.

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NCAM/CD56 Antibody (2Q692) References:

1. Differential expression of two adhesion molecules of the immunoglobulin superfamily, F3 and polysialylated NCAM, in hypothalamic magnocellular neurones capable of plasticity.  |  Theodosis, DT., et al. 2000. Exp Physiol. 85 Spec No: 187S-196S. PMID: 10795922
2. Identification of NCAM-binding peptides promoting neurite outgrowth via a heterotrimeric G-protein-coupled pathway.  |  Hansen, RK., et al. 2007. J Neurochem. 103: 1396-407. PMID: 17854387
3. NCAM-derived peptides function as agonists for the fibroblast growth factor receptor.  |  Hansen, SM., et al. 2008. J Neurochem. 106: 2030-41. PMID: 18624916
4. Vulnerability of conditional NCAM-deficient mice to develop stress-induced behavioral alterations.  |  Bisaz, R. and Sandi, C. 2012. Stress. 15: 195-206. PMID: 21939373
5. PSA modification of NCAM supports the survival of injured retinal ganglion cells in adulthood.  |  Lobanovskaya, N., et al. 2015. Brain Res. 1625: 9-17. PMID: 26319680
6. NCAM affects directional lamellipodia formation of BMSCs via β1 integrin signal-mediated cofilin activity.  |  Bi, JJ., et al. 2017. Mol Cell Biochem. 435: 175-183. PMID: 28536952
7. Development and validation of an immunoassay for quantification of NCAM-1 in human plasma.  |  Guven, A., et al. 2021. J Pharm Biomed Anal. 197: 113981. PMID: 33657526
8. The Graphical Studies of the Major Molecular Interactions for Neural Cell Adhesion Molecule (NCAM) Polysialylation by Incorporating Wenxiang Diagram into NMR Spectroscopy.  |  Zhou, GP. and Huang, RB. 2022. Int J Mol Sci. 23: PMID: 36499451
9. NCAM requires a cytoplasmic domain to function as a neurite outgrowth-promoting neuronal receptor.  |  Saffell, JL., et al. 1995. Mol Cell Neurosci. 6: 521-31. PMID: 8742269
10. NCAM-mediated adhesion of transfected cells to agrin.  |  Storms, SD., et al. 1996. Cell Adhes Commun. 3: 497-509. PMID: 8807193

The preferred NCAM/CD56 antibody is NCAM/CD56 Antibody (ERIC 1): sc-106.