MIF Antibody (4E4): sc-53915

MIF Antibody (4E4) is a mouse monoclonal IgG1 antibody that detects macrophage migration inhibitory factor (MIF) in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Anti-MIF antibody (4E4) recognizes MIF, a secreted, homotrimeric pro-inflammatory cytokine that plays a crucial role in modulating immune responses, particularly in macrophages and T cells. MIF is primarily produced by the pituitary gland and is expressed in various immune cells, including monocytes and macrophages, as well as in fibroblasts and differentiating immunological cells in the eye lens and brain. MIF is notably involved in the host′s response to infection, especially at sites of inflammation, where MIF regulates macrophage function and influences the production of other inflammatory cytokines such as tumor necrosis factor α (TNFα), interleukin-1 (IL-1), and interferon-γ (IFN-γ). MIF undergoes post-translational modifications, including glycosylation, which can affect stability, secretion, and interaction with receptors, thereby influencing biological activity and the overall inflammatory response. Elevated levels of MIF have been associated with severe sepsis and septic shock, highlighting significance in pathological conditions. MIF monoclonal antibody (4E4) is an essential tool for researchers studying the intricate roles of MIF in immune regulation and inflammation.

The preferred MIF antibody is MIF Antibody (D-2): sc-271631.