Lipid A Antibody (26-5): sc-57902

Lipid A Antibody (26-5) is a mouse monoclonal IgG2b antibody that detects Lipid A protein of non-species reactive by enzyme-linked immunosorbent assay (ELISA). Anti-Lipid A antibody (26-5) is available as a non-conjugated monoclonal isotype antibody. Lipid A, a crucial component of the lipopolysaccharide (LPS) found in the outer membrane of Gram-negative bacteria, consists of two glucosamine units linked to acyl chains and typically features a phosphate group on each sugar. The structure of Lipid A serves as the anchor for LPS, which is essential for maintaining the integrity of the bacterial outer membrane. This structural role contributes to the stability of the bacterial cell wall and plays a critical part in the pathogenicity of Gram-negative bacteria. The human immune system recognizes Lipid A as a potent trigger for immune responses, which is crucial for combating infections. However, when present in excessive amounts during infections, Lipid A can lead to severe immune reactions, including septic shock, highlighting its importance in both bacterial survival and host immune interactions.

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Lipid A Antibody (26-5) References:

1. Chemical characterization of lipid A from some marine proteobacteria.  |  Krasikova, IN., et al. 2001. Biochemistry (Mosc). 66: 1047-54. PMID: 11703190
2. Role of innate immune factors in the adjuvant activity of monophosphoryl lipid A.  |  Martin, M., et al. 2003. Infect Immun. 71: 2498-507. PMID: 12704121
3. Burkholderia cenocepacia lipopolysaccharide, lipid A, and proinflammatory activity.  |  De Soyza, A., et al. 2004. Am J Respir Crit Care Med. 170: 70-7. PMID: 15044201
4. Variation in lipid A structure in the pathogenic yersiniae.  |  Rebeil, R., et al. 2004. Mol Microbiol. 52: 1363-73. PMID: 15165239
5. Differential TLR recognition of leptospiral lipid A and lipopolysaccharide in murine and human cells.  |  Nahori, MA., et al. 2005. J Immunol. 175: 6022-31. PMID: 16237097
6. Synthesis of lipid A and its analogues for investigation of the structural basis for their bioactivity.  |  Fujimoto, Y., et al. 2005. J Endotoxin Res. 11: 341-7. PMID: 16303089
7. Unraveling the mystery of gammadelta T cell recognizing lipid A.  |  Cui, Y., et al. 2005. Cell Mol Immunol. 2: 359-64. PMID: 16368062
8. Structural similarity between the hydrophobic fluorescent probe and lipid A as a ligand of MD-2.  |  Mancek-Keber, M. and Jerala, R. 2006. FASEB J. 20: 1836-42. PMID: 16940155
9. Synthetic triacylated lipid A derivative activates antigen presenting cells via the TLR4 pathway and promotes antigen-specific responses in vivo.  |  Savoy, F., et al. 2006. Immunobiology. 211: 767-77. PMID: 17113914