Lipid A Inhibitors
Lipid A Inhibitors are a class of chemical compounds designed to interact with Lipid A, a critical component of the lipopolysaccharides (LPS) found in the outer membrane of Gram-negative bacteria. Lipid A is responsible for the structural integrity of the bacterial membrane and plays a pivotal role in the activation of immune responses due to its endotoxic properties. By targeting Lipid A, these inhibitors aim to interfere with the biological activities mediated by this lipid molecule, such as its ability to trigger signaling pathways that lead to inflammation.
Chemically, Lipid A Inhibitors often consist of molecules that can bind to the lipid's unique disaccharide backbone or its acyl chains. These compounds may mimic the structural features of Lipid A or possess functional groups that allow them to interact specifically with the phosphate groups or ester linkages within Lipid A. The interaction between the inhibitors and Lipid A can lead to alterations in the conformation or stability of the lipopolysaccharide layer, potentially disrupting membrane function. Additionally, some inhibitors may interfere with the biosynthesis of Lipid A by targeting enzymes involved in its assembly, thereby affecting the overall production of LPS in the bacterial cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triclosan | 3380-34-5 | sc-220326 sc-220326A | 10 g 100 g | $141.00 $408.00 | ||
Triclosan is an antimicrobial agent that inhibits fatty acid synthesis by targeting enoyl-acyl carrier protein reductase (FabI) in bacteria. This action leads to a reduction in the production of fatty acids necessary for Lipid A biosynthesis, thereby indirectly inhibiting its formation and compromising bacterial membrane integrity. | ||||||
Ebselen | 60940-34-3 | sc-200740B sc-200740 sc-200740A | 1 mg 25 mg 100 mg | $33.00 $136.00 $458.00 | 5 | |
Ebselen is a selenium-containing compound with anti-inflammatory properties. It interferes with bacterial thioredoxin reductase, an enzyme involved in the reduction of oxidative stress within cells. By impairing this system, ebselen indirectly affects the biosynthetic pathways necessary for Lipid A production, contributing to bacterial growth inhibition. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a polyphenolic compound from turmeric, exhibits broad antimicrobial activity. It disrupts bacterial cell membranes and interferes with the quorum sensing system, which is crucial for bacterial communication and virulence factor regulation, including enzymes involved in Lipid A biosynthesis. This disruption indirectly inhibits Lipid A production. | ||||||
Platensimycin | 835876-32-9 | sc-202292 | 250 µg | $462.00 | 1 | |
Platensimycin is a natural antibiotic that targets bacterial fatty acid synthase (FASII), a key enzyme in the fatty acid biosynthesis pathway. By inhibiting FASII, platensimycin reduces the availability of fatty acids necessary for the synthesis of Lipid A, thereby indirectly impeding its production and affecting bacterial viability. | ||||||
Cerulenin (synthetic) | 17397-89-6 | sc-200827 sc-200827A sc-200827B | 5 mg 10 mg 50 mg | $161.00 $312.00 $1210.00 | 9 | |
Cerulenin, a natural product from Cephalosporium caerulens, inhibits fatty acid synthase, an enzyme critical for fatty acid biosynthesis. This inhibition decreases the precursors required for Lipid A biosynthesis, thereby indirectly reducing its production and impacting bacterial membrane composition and function. | ||||||
Isoniazid | 54-85-3 | sc-205722 sc-205722A sc-205722B | 5 g 50 g 100 g | $26.00 $101.00 $146.00 | ||
Isoniazid inhibits the synthesis of mycolic acids, essential components of mycobacterial cell walls. Though not directly affecting Lipid A, isoniazid's mechanism suggests potential for indirect inhibition of similar pathways in Gram-negative bacteria, affecting cell wall integrity. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin binds to bacterial RNA polymerase, inhibiting RNA synthesis. This action can indirectly affect the expression of genes involved in Lipid A biosynthesis, thereby potentially reducing its production and impacting bacterial membrane stability and function. | ||||||
Norfloxacin | 70458-96-7 | sc-215586 | 10 g | $125.00 | 1 | |
Norfloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication. Indirectly, this inhibition could affect the transcription and translation of genes involved in Lipid A biosynthesis, leading to reduced production. | ||||||
Azithromycin | 83905-01-5 | sc-254949 sc-254949A sc-254949B sc-254949C sc-254949D | 25 mg 50 mg 500 mg 1 g 5 g | $52.00 $103.00 $260.00 $364.00 $728.00 | 17 | |
Azithromycin, a macrolide antibiotic, inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. This action may indirectly influence the synthesis of enzymes and other proteins involved in Lipid A biosynthesis, potentially leading to its reduced production. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
Daptomycin is a lipopeptide antibiotic that disrupts bacterial cell membrane function. While its primary action is not directly on Lipid A, disrupting membrane function could indirectly affect the assembly or function of Lipid A in the outer membrane, impacting bacterial viability. | ||||||