LFM-A12
Application:
LFM-A12 is a potent and specific inhibitor of EGFR tyrosine kinase activity
Molecular Weight:
286.2
Molecular Formula:
C12H9F3N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
LFM-A12 is a potent and specific inhibitor of the EGFR tyrosine kinase in vitro (IC50 = 1.7 μM). Has been shown to kill over 99% of human breast cancer cells in vitro by triggering apoptosis. Even at high concentrations (175-350 μM), LFM-A12 does not affect the enzymatic activity of other PTKs including BTK, HCK, IRK, JAK1, JAK3, and Syk.
LFM-A12 References
Ghosh, S., et al. 1999. Clin. Cancer Res. 5, 4264. Mahajan, S., et al. 1999. J. Biol. Chem. 274, 9587. Ghosh, S., et al. 1998. Clin. Cancer Res. 4, 2657.Inhibitor of:
EGFR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LFM-A12, 500 µg | sc-295360 | 500 µg | $296.00 | |||
LFM-A12, 1 mg | sc-295360A | 1 mg | $400.00 |