Integrin αM/CD11b Antibody (2LPM19c): sc-20050

Integrin αM Antibody (2LPM19c) is a mouse monoclonal IgG1 kappa light chain antibody specifically designed to target Integrin αM, also known as CD11b, ITGAM, Mac-1, or complement component receptor-3 α (CR3α). Integrin αM monoclonal antibody (2LPM19c) is raised against the purified C3bi receptor and demonstrates strong reactivity with Integrin αM from human, mouse, and rat origins, making anti-Integrin αM antibody (2LPM19c) ideal for a variety of applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Integrin αM is a crucial cell adhesion molecule located on the plasma membrane of leukocytes, where Integrin αM mediates the adherence of neutrophils and monocytes to activated endothelial cells, thereby facilitating immune cell migration and effective immune responses. Additionally, Integrin αM forms a heterodimer with Integrin β2, creating the Mac-1 (CR3) complex, which is essential for the phagocytosis of complement-coated pathogens and cellular debris, playing a vital role in maintaining immune surveillance and homeostasis. The strategic cell surface localization of Integrin αM allows interaction with various intracellular adhesion molecules (ICAMs) and soluble ligands, highlighting Integrin αM′s importance in immune regulation and inflammatory processes. Integrin αM (2LPM19c) antibody is available in both conjugated and non-conjugated forms, including horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® variants, providing researchers with versatile options to meet experimental needs. By effectively targeting Integrin αM, Integrin αM monoclonal antibody (2LPM19c) facilitates comprehensive studies on immune cell behavior, the mechanisms underlying immune-mediated diseases, and the development of therapeutic interventions, making anti-Integrin αM antibody (2LPM19c) an indispensable tool for advanced immunological research.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Integrin αM/CD11b Antibody (2LPM19c) has 30 citations in a variety of scientific publications.

Primary antibodies like Anti-Integrin αM/CD11b Antibody (2LPM19c) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Integrin αM/CD11b Antibody (2LPM19c) Specifications

Alternate Product Name: ITGAM

Product Clone Name: 2LPM19c

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Integrin αM

Epitope Species: human

Product Reactivity/Detection: Integrin αM

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 30 citations in various scientific publications

Available Conjugates/Forms for Integrin αM/CD11b Antibody (2LPM19c): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, PE: Phycoerythrin

The preferred Integrin αM/CD11b antibody is Integrin αM/CD11b Antibody (OX42): sc-53086.