IKKγ Antibody (72C627): sc-56919

IKKγ Antibody (72C627) is a mouse monoclonal IgG1 antibody engineered to detect IKKγ, also known as NEMO (NF-κB Essential Modulator), in human samples using western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). IKKγ is a pivotal regulatory subunit of the IKK complex, characterized by its intricate structure that includes zinc finger domains, a coiled-coil region, and a ubiquitin-binding domain, which are essential for its role in facilitating protein-protein interactions and maintaining the structural integrity of the complex. This structural configuration is crucial for the activation of the NF-κB signaling pathway, as IKKγ mediates the phosphorylation and subsequent degradation of IκB inhibitors, allowing NF-κB to translocate to the nucleus and regulate genes involved in immune responses, inflammation, and cell survival. Post-translational modifications, particularly ubiquitination, play a significant role in regulating IKKγ′s activity and interactions with other proteins such as IKKα and IKKβ, thereby controlling the intensity and duration of the NF-κB response. IKKγ interacts with various proteins, including ubiquitin ligases and kinases, which are essential for its function in signal transduction and cellular responses to proinflammatory cytokines. By targeting the full-length native IKKγ, anti-IKKγ antibody (72C627) ensures accurate detection and analysis of this protein′s interactions and modifications, providing researchers with a reliable tool to investigate the molecular mechanisms underlying diseases like cancer, autoimmune disorders, and chronic inflammation.

The preferred IKKγ antibody is IKKγ Antibody (B-3): sc-8032.