HDAC para análisis funcionales de las repuestas celulares a HDAC
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In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated RPD3) and HDAC3, all of which are related to the yeast transcriptional factor Rpd3p, have been identified as histone deacetylases.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Can HDAC3 (3G6): sc-81600 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?
Preguntado por: Dr Ninau Qelp
Thank you for your question. Yes, HDAC3 (3G6): sc-81600 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here:
Rated 4 de
Positive immunoperoxidase staining of formalinPositive immunoperoxidase staining of formalin fixed, paraffin-embedded human cerebellum tissue showing nuclear and cytoplasmic staining of Purkinje cells and nuclear staining of cells in molecular layer.
Fecha de publicación: 2015-03-11
Rated 4 de
Western blot publication using human ProstateWestern blot publication using human Prostate Tissue -SCBT Publication Review
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