HDAC para análisis funcionales de las repuestas celulares a HDAC
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Animal Health Prescription Item
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
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Labware ships FedEx Ground free of charge to the contiguous US
HDAC10 Antibody (E-2) is a high quality monoclonal HDAC10 antibody (also designated Histone Deacetylase 10 antibody) suitable for the detection of the HDAC10 protein of mouse, rat and human origin. HDAC10 Antibody (E-2) is available as both the non-conjugated anti-HDAC10 antibody form, as well as multiple conjugated forms of anti-HDAC10 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Histone deacetylases (HDACs) play an important role in the modification of chromatin structure and thus in the suppression and activation of transcription and cellular differentiation. There are 11 members in the HDAC family that are divided into four classes. Class I HDACs represent homologs of the yeast histone deacetylase Rpd3, class II HDACs share strong homology with the yeast histone deacetylase Hda1, class III HDACs are closely related to the yeast Sir2 protein and class IV HDACs comprise histone deacetylase 11 (HDAC11)-related enzymes. HDAC10, also known as HD10, is a member of the class II HDACs. It contains an N-terminal Hda1p-related catalytic domain and a unique C-terminal leucine-rich domain. HDAC10 is ubiquitously expressed and can shuttle between the cytoplasm and nucleus in response to celllular signals. It is able to repress transcription and, like other class II HDAC members, its enzymatic activity is inhibited by Trichostatin A (TSA).
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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