Ganglioside GD3 Antibody (4i262): sc-71138

Ganglioside GD3 Antibody (4i262) is a mouse monoclonal IgG3 antibody that detects Ganglioside GD3 in non-species reactive samples through immunofluorescence (IF) applications. Ganglioside GD3 is a crucial membrane-bound glycosphingolipid that contains sialic acid and plays a significant role in cell signaling and interaction, particularly in tetraspanin interactions. Synthesis involves the transfer of sialic acid from CMP-sialic acid to GM3, a reaction catalyzed by the type II membrane protein GD3 Synthase. Ganglioside GD3 is vital for cell adhesion and the growth of malignant cells, making Ganglioside GD3 a key player in cancer biology. Expression is not only prevalent in most normal tissues but also increases under pathological conditions, during development, and throughout aging. In malignant melanoma cells, Ganglioside GD3 is implicated in the upregulation of tyrosine phosphorylation of proteins such as p130 Cas and paxillin, which are essential for cellular signaling pathways. Ganglioside GD3 has been shown to mediate apoptosis, acting as a regulatory molecule that contributes to mitochondrial damage, thereby influencing cell fate. The level of Ganglioside GD3 within a cell is a critical determinant of survival and function, underscoring the importance of anti-Ganglioside GD3 antibody (4i262) in research and therapeutic applications.

The preferred Ganglioside GD3 antibody is Ganglioside GD3 Antibody (MB3.6): sc-33685.