FTY720 Phosphate CAS: 402615-91-2
MF: C19H34NO5P
MW: 387.50
A derivative of ISP-1 that is a fungal metabolite as well as a structural analog of sphingosine.

FTY720 Phosphate (CAS 402615-91-2)

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FTY720 Phosphate is rated 5.0 out of 5 by 1.
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Nombres Alternativos: 2- amino- 2[2- (4- octylphenyl)ethyl]- 1, 3- propanediol, mono dihydrogen phosphate ester
Solicitud: FTY720 Phosphate is a derivative of ISP-1 that is a fungal metabolite as well as a structural analog of sphingosine
Número de CAS: 402615-91-2
Pureza: >98%
Peso Molecular: 387.50
Fórmula Molecular: C19H34NO5P
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
* En el Certificado de Análisis específico de lote, puede encontrar información específica (como el contenido en agua).

FTY720 Phosphate is a derivative of ISP-1 (myriocin) that is a fungal metabolite of the Chinese herb Iscaria sinclarii and a structural analog of sphingosine. FTY720 is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. It is phosphorylated by sphingosine kinase to the physiologically active phosphoric acid ester. FTY720 phosphate acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (EDG-1, EDG-3, EDG-4, and EDG-5), with IC50 values of 0.2-6 nM.


References

1 Brinkmann, V., Pinschewer, D.D., Feng, L., et al. FTY720: Altered lymphocyte traffic results in allograft protection. Transplantation 72 764-769 (2001). 2 Brinkmann, V., Davis, M.D., Heise, C.E., et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem 277(24) 21453-21457 (2002). 3 Mandala, S., Hajdu, R., Bergstrom, J., et al. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 296 346-349 (2002). 4 Forrest, M., Sun, S., Hajdu, R., et al. Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes. J Pharmacol Exp Ther 309(2) 758-768 (2004).

Estado de Materia :
Solid
Solubilidad :
Soluble in chloroform ( ~0.5 mg/ml).
ALMACENAMIENTO :
Store at -20° C
Punto de Fusión :
90.27° C
Punto de ebullición :
584.24° C at 760 mmHg (Predicted)
Densidad :
1.17 g/cm3 (Predicted)
Indice de Refracción :
n20D 1.54 (Predicted)
IC50 :
EDG-1: IC50 = 0.28 nM (human); EDG-8: IC50 = 0.77 nM (human); EDG-5: IC50 = 0.77 nM (human); EDG-3: IC50 = 6.3 nM (human); EDG-6: IC50 = 15 nM (human)
Valores de pK :
pKa: 1.73 (Predicted), pKb: 10.04 (Predicted)
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
PubChem CID :
Número MDL :
MFCD18251416
SMILES :
CCCCCCCCC1=CC=C(C=C1)CCC(CO)(COP(=O)(O)O)N

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PMID: # 27501354  Al Alam, N.|Kreydiyyeh, SI.| et al. 2016. Biochem Cell Biol. 94: 371-7.

PMID: # 24029635  Kraft, P. et al. 2013. Stroke. 44: 3202-10.

PMID: # 24231649  Kajimoto, T. et al. 2013. Nat Commun. 4: 2712.

PMID: # 19619245  Ohno, Y. et al. 2009. Genes Cells. 14: 911-923.

PMID: # 16549044  Chiba, K. et al. 2006. Cell. Mol. Immunol. 3: 11-19.

Citaciones 1 a 5 de un total de 5
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