Fos B Antibody (F-7): sc-398595

FosB Antibody (F-7) is a mouse monoclonal IgG1 kappa light chain antibody raised against amino acids 75-150 of human FosB, a crucial transcription factor that regulates cellular responses to diverse stimuli. Anti-FosB antibody (F-7) recognizes an epitope within this region and demonstrates broad species cross-reactivity, detecting FosB in mouse, rat, and human samples through Western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry on paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA) applications. As a nuclear phosphoprotein, FosB undergoes sophisticated regulation through post-translational modifications, particularly phosphorylation, which fine-tunes FosB′s stability, subcellular localization, and ability to form complexes with Jun family proteins. These modifications prove essential for FosB′s capacity to bind TPA response elements (TREs) in DNA, enabling precise control of genes involved in proliferation, differentiation, and apoptosis. Through this intricate regulatory network responding to growth factors, stress signals, and other molecular cues, FosB serves as a critical coordinator of transcriptional responses. Through these diverse cellular functions, FosB (F-7) antibody provides researchers with a valuable tool for investigating transcriptional regulation and cellular homeostasis mechanisms.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Fos B Antibody (F-7) References:

1. Enhanced binding activity of nuclear antioxidant-response element through possible formation of Nrf2/Fos-B complex after in vivo treatment with kainate in murine hippocampus.  |  Ogita, K., et al. 2004. Neuropharmacology. 46: 580-9. PMID: 14975682
2. Impaired ventilatory acclimatization to hypoxia in mice lacking the immediate early gene fos B.  |  Malik, MT., et al. 2005. Respir Physiol Neurobiol. 145: 23-31. PMID: 15652785
3. Sequential expression of JUN B, JUN D and FOS B proteins in rat spinal neurons: cascade of transcriptional operations during nociception.  |  Herdegen, T., et al. 1991. Neurosci Lett. 129: 221-4. PMID: 1745403
4. Overexpression of c-jun, junB, or junD affects cell growth differently.  |  Castellazzi, M., et al. 1991. Proc Natl Acad Sci U S A. 88: 8890-4. PMID: 1924349
5. Isolation and characterization of fra-2, an additional member of the fos gene family.  |  Nishina, H., et al. 1990. Proc Natl Acad Sci U S A. 87: 3619-23. PMID: 2110368
6. The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity.  |  Zerial, M., et al. 1989. EMBO J. 8: 805-13. PMID: 2498083
7. An avian transforming retrovirus isolated from a nephroblastoma that carries the fos gene as the oncogene.  |  Nishizawa, M., et al. 1987. J Virol. 61: 3733-40. PMID: 2824811
8. Chromatin association and DNA binding properties of the c-fos proto-oncogene product.  |  Renz, M., et al. 1987. Nucleic Acids Res. 15: 277-92. PMID: 3103098
9. The Fos protein complex is associated with DNA in isolated nuclei and binds to DNA cellulose.  |  Sambucetti, LC. and Curran, T. 1986. Science. 234: 1417-9. PMID: 3491427
10. Virus induction of osteosarcomas in mice.  |  Finkel, MP., et al. 1966. Science. 151: 698-701. PMID: 5218049
11. FBR murine osteosarcoma virus. I. Molecular analysis and characterization of a 75,000-Da gag-fos fusion product.  |  Curran, T. and Verma, IM. 1984. Virology. 135: 218-28. PMID: 6203214
12. Fos family member changes in nucleus caudalis neurons after primary afferent stimulation: enhancement of fos B and c-fos.  |  Walther, D., et al. 1993. Brain Res Mol Brain Res. 17: 155-9. PMID: 8381898

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Fos B Antibody (F-7) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-Fos B Antibody (F-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Fos B Antibody (F-7) Specifications

Alternate Product Name: FosB

Product Clone Name: F-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 75-150

Epitope Target: Fos B

Epitope Species: human

Product Reactivity/Detection: Fos B

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for Fos B Antibody (F-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent

The preferred c-Fos antibody is c-Fos Antibody (D-1): sc-8047.