FK-506 Antibody (FK1): sc-51900

FK-506 Antibody (FK1) is a mouse monoclonal IgM antibody that detects FK-506 protein of various species by western blotting (WB). Anti-FK-506 antibody (FK1) is available as a non-conjugated format, specifically designed to provide reliable detection of FK-506, also known as Tacrolimus or Fujimycin, which is a 23-membered macrolide lactone recognized for its potent immunosuppressive properties, surpassing those of cyclosporine. FK-506 (FK1) monoclonal antibody plays a critical role in preventing organ rejection in solid organ transplant patients, where FK-506 is utilized for both primary and rescue immunosuppression. Notably, FK-506 undergoes various post-translational modifications, including phosphorylation, which can significantly influence pharmacokinetics and therapeutic efficacy. These modifications are crucial as they can affect drug interaction with target receptors and overall immunosuppressive activity, thereby necessitating careful therapeutic drug monitoring to optimize treatment outcomes. Monitoring FK-506 levels in whole blood is essential, with target therapeutic ranges typically between 3.0 and 20.0 ng/ml, depending on individual patient factors such as liver function and type of organ transplanted. Anti-FK-506 antibody (FK1) serves as a valuable tool in research and clinical settings, aiding in understanding and management of FK-506 therapy.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

FK-506 Antibody (FK1) References:

1. [Establishment of a cell model targeted to NFAT signal transduction pathway for preliminary screening of FK506-like immunosuppressants].  |  Xiao, H., et al. 2005. Sheng Wu Gong Cheng Xue Bao. 21: 759-65. PMID: 16285518
2. Neuroprotective effects of tacrolimus (FK506) in a model of ischemic cortical cell cultures: role of glutamate uptake and FK506 binding protein 12 kDa.  |  Labrande, C., et al. 2006. Neuroscience. 137: 231-9. PMID: 16289353
3. The immunosuppressive agent FK506 enhances the cytolytic activity of inhibitory natural killer cell receptor (CD94/NKG2A)-expressing CD8 T cells.  |  Tanaka, J., et al. 2005. Transplantation. 80: 1813-5. PMID: 16378079
4. Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421.  |  Pardo, R., et al. 2006. J Neurosci. 26: 1635-45. PMID: 16452687
5. An analog of a dipeptide-like structure of FK506 increases glial cell line-derived neurotrophic factor expression through cAMP response element-binding protein activated by heat shock protein 90/Akt signaling pathway.  |  Cen, X., et al. 2006. J Neurosci. 26: 3335-44. PMID: 16554484
6. Nerve regeneration through nerve autografts and cold preserved allografts using tacrolimus (FK506) in a facial paralysis model: a topographical and neurophysiological study in monkeys.  |  Hontanilla, B., et al. 2006. Neurosurgery. 58: 768-79; discussion 768-79. PMID: 16575341
7. [Favorable effect of chitosan sustained-release FK506 incorporated conduits on axonal regeneration in rat sciatic nerve].  |  Zhang, WG., et al. 2006. Zhonghua Yi Xue Za Zhi. 86: 1065-8. PMID: 16784713
8. Comparison of rapamycin versus FK506 on expression of cytoprotective genes in the rat kidney allografts undergoing chronic allograft nephropathy.  |  Teng, D., et al. 2006. Transplant Proc. 38: 2172-5. PMID: 16980034
9. FK506 may reduce early liver injury following living related liver transplantation.  |  Kato, T., et al. 2006. Hepatogastroenterology. 53: 580-3. PMID: 16995466

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FK-506 Antibody (FK1) has 1 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FK-506 Antibody (FK1) Specifications

Alternate Product Name: FK-506

Product Clone Name: FK1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM

Amino Acids:

Epitope Target: FK-506

Epitope Species:

Product Reactivity/Detection: conjugated and non-conjugated FK-506

Species Reactivity/Detection: N/A

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB

Vialing Information: Each vial contains 100 µg IgM in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for FK-506 Antibody (FK1): N/A