emerin Antibody (F-11): sc-398278
- emerin Antibody (F-11) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 196-223 near the C-terminus of emerin of human origin
- recommended for detection of emerin of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for emerin Antibody (F-11) for WB applications. These reagents are now offered in bundles with emerin Antibody (F-11) (see ordering information below).
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SEE ALSO...
Emerin Antibody (F-11) is a mouse monoclonal IgG1 antibody that detects emerin in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Emerin is a crucial component of the nuclear lamina, playing a significant role in maintaining the structural integrity of the nuclear envelope and facilitating chromatin organization. Emerin′s proper localization to the nuclear membrane is vital for cellular function, as anti-emerin antibody (F-11) helps anchor the nuclear lamina to the inner nuclear membrane, thereby influencing gene expression and cellular signaling pathways. Mutations in the gene encoding emerin can lead to the X-linked recessive disorder Emery-Dreyfuss muscular dystrophy (EDMD), which manifests as progressive muscle weakness, contractures, and cardiac issues. Emerin′s absence disrupts the normal association between the nuclear membrane and the lamina, contributing to EDMD pathophysiology. Emerin′s localization to desmosomes and fasciae adherentes in cardiac tissue may explain the conduction defects observed in affected individuals, highlighting emerin′s critical role in both muscle and cardiac health.
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emerin Antibody (F-11) References:
- Effect of pathogenic mis-sense mutations in lamin A on its interaction with emerin in vivo. | Holt, I., et al. 2003. J Cell Sci. 116: 3027-35. PMID: 12783988
- Emerin-lacking mice show minimal motor and cardiac dysfunctions with nuclear-associated vacuoles. | Ozawa, R., et al. 2006. Am J Pathol. 168: 907-17. PMID: 16507906
- Emerin inhibits Lmo7 binding to the Pax3 and MyoD promoters and expression of myoblast proliferation genes. | Dedeic, Z., et al. 2011. J Cell Sci. 124: 1691-702. PMID: 21525034
- Loss of emerin alters myogenic signaling and miRNA expression in mouse myogenic progenitors. | Koch, AJ. and Holaska, JM. 2012. PLoS One. 7: e37262. PMID: 22606356
- EBV early lytic protein BFRF1 alters emerin distribution and post-translational modification. | Yadav, S., et al. 2017. Virus Res. 232: 113-122. PMID: 28238874
- Hop/STIP1 depletion alters nuclear structure via depletion of nuclear structural protein emerin. | Kituyi, SN. and Edkins, AL. 2018. Biochem Biophys Res Commun. 507: 503-509. PMID: 30449594
- Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus. | Ranade, D., et al. 2019. BMC Mol Cell Biol. 20: 11. PMID: 31117946
- Comparative Interactome Analysis of Emerin, MAN1 and LEM2 Reveals a Unique Role for LEM2 in Nucleotide Excision Repair. | Moser, B., et al. 2020. Cells. 9: PMID: 32085595
- Role of Lamin A and emerin in maintaining nuclear morphology in different subtypes of ovarian epithelial cancer. | Watabe, S., et al. 2022. Oncol Lett. 23: 9. PMID: 34820008
- Emerin deficiency at the nuclear membrane in patients with Emery-Dreifuss muscular dystrophy. | Nagano, A., et al. 1996. Nat Genet. 12: 254-9. PMID: 8589715
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
emerin Antibody (F-11) | sc-398278 | 200 µg/ml | $322.00 | |||
emerin Antibody (F-11): m-IgG Fc BP-HRP Bundle | sc-540926 | 200 µg Ab; 10 µg BP | $361.00 | |||
emerin Antibody (F-11): m-IgG1 BP-HRP Bundle | sc-542467 | 200 µg Ab; 20 µg BP | $361.00 | |||
emerin (F-11) Neutralizing Peptide | sc-398278 P | 100 µg/0.5 ml | $69.00 |