EBV EBNA-1 Antibody (1EB14): sc-81582

EBV EBNA-1 Antibody (1EB14) is a mouse monoclonal IgG1 antibody that detects EBV EBNA-1 in human samples by western blotting (WB) and immunoprecipitation (IP). EBV EBNA-1 is a crucial protein expressed in all Epstein-Barr virus-associated tumors, including Burkitt′s lymphoma and nasopharyngeal carcinoma, and plays a vital role in the synthesis and maintenance of the Epstein-Barr virus genome. EBV EBNA-1 is essential for the transformation of human B cells, facilitating the replication of the viral genome and the expression of latent genes necessary for the growth and immortalization of these cells. Notably, EBV EBNA-1 interacts with various cellular proteins, including the cellular transcription factor Oct-2, which enhances viral gene expression activation. EBV EBNA-1 presence in infected cells is not only a marker for EBV-related malignancies but also highlights its importance in the pathogenesis of these diseases, making EBV EBNA-1 a significant target for research and therapeutic interventions. Anti-EBV EBNA-1 antibody (1EB14) serves as an invaluable tool for studying the role of EBV in cancer biology and for exploring potential treatment strategies.

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EBV EBNA-1 Antibody (1EB14) References:

1. Epstein-barr virus nuclear antigen 1: from immunologically invisible to a promising T cell target.  |  Münz, C. 2004. J Exp Med. 199: 1301-4. PMID: 15148332
2. Transcription profiling of Epstein-Barr virus nuclear antigen (EBNA)-1 expressing cells suggests targeting of chromatin remodeling complexes.  |  Sompallae, R., et al. 2010. PLoS One. 5: e12052. PMID: 20706582
3. Epstein-Barr Virus nuclear antigen 1 (EBNA1) confers resistance to apoptosis in EBV-positive B-lymphoma cells through up-regulation of survivin.  |  Lu, J., et al. 2011. Virology. 410: 64-75. PMID: 21093004
4. Epstein-Barr Virus Nuclear Antigen 1 Recruits Cyclophilin A to Facilitate the Replication of Viral DNA Genome.  |  Xin, S., et al. 2019. Front Microbiol. 10: 2879. PMID: 31921057
5. Mechanisms of Epstein-Barr virus nuclear antigen 1 favor Tregs accumulation in nasopharyngeal carcinoma.  |  Wang, J., et al. 2020. Cancer Med. 9: 5598-5608. PMID: 32573058
6. Detection of Epstein Barr Nuclear Antigen-1 (EBNA-1), Early Antigen 1F, 2R (EA-1F, EA- 2R) along with Epstein-Barr virus Latent Membrane Protein 1 (LMP1) in Breast Cancer of Northern India: An Interim Analysis.  |  Shahi, V., et al. 2022. Asian Pac J Cancer Prev. 23: 3717-3723. PMID: 36444584
7. Epstein-Barr Virus Nuclear Antigen 1 Increases the Expression of Viral Oncogenes and Cellular Genes in the HeLa Cell Line.  |  Alipour, AH., et al. 2022. Int J Mol Cell Med. 11: 346-356. PMID: 37727642
8. Specific antibodies to EBNA1 epitopes as risk factors for multiple sclerosis, a systematic review.  |  Roshan, HM., et al. 2023. J Neuroimmunol. 383: 578202. PMID: 37751637
9. The Epstein-Barr Virus Nuclear Antigen 1 Variant Associated with Nasopharyngeal Carcinoma Defines the Sequence Criteria for Serologic Risk Prediction.  |  Warner, BE., et al. 2024. Clin Cancer Res. 30: 5207-5217. PMID: 39264275
10. Epstein Barr virus (EBV)-carrying cells of a chronic lymphocytic leukemia (CLL) subpopulation express EBNA1 and LMPS but not EBNA2 in vivo.  |  Laytragoon-Lewin, N., et al. 1996. Int J Cancer. 65: 714-5. PMID: 8598328

The preferred EBV EBNA-1 antibody is EBV EBNA-1 Antibody (1EB12): sc-81581.