Drebrin Antibody (B-6): sc-393097
- Drebrin Antibody (B-6) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 31-186 mapping near the N-terminus of Drebrin of human origin
- recommended for detection of Drebrin isoforms A and B of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine and porcine
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Drebrin Antibody (B-6) for WB applications. These reagents are now offered in bundles with Drebrin Antibody (B-6) (see ordering information below).
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Drebrin Antibody (B-6) is a mouse monoclonal IgG1 antibody that detects Drebrin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Drebrin antibody (B-6) specifically targets Drebrin, which plays a crucial role in the brain by binding to F-actin, thereby influencing cell migration, the extension of neuronal processes, and the plasticity of dendrites. Drebrin (B-6) antibody recognizes a protein essential for maintaining the structural integrity and functionality of synapses, which are vital for effective neuronal communication and cognitive processes. Drebrin is predominantly expressed in brain neurons, but can also be found in skeletal muscle, heart, placenta, pancreas, and kidney. Drebrin′s presence in dendritic spines makes this protein a significant marker for studying synaptic changes associated with neurodegenerative diseases. Alterations in Drebrin levels have been linked to conditions such as Alzheimer′s disease and Down syndrome, highlighting Drebrin′s potential as a biomarker for these disorders. The gene encoding Drebrin is located on chromosome 5, and understanding Drebrin expression and regulation can provide insights into the underlying mechanisms of various neurological conditions.
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Drebrin Antibody (B-6) References:
- Drebrin-induced stabilization of actin filaments. | Mikati, MA., et al. 2013. J Biol Chem. 288: 19926-38. PMID: 23696644
- Drebrin inhibits cofilin-induced severing of F-actin. | Grintsevich, EE. and Reisler, E. 2014. Cytoskeleton (Hoboken). 71: 472-83. PMID: 25047716
- Drebrin regulates neuroblast migration in the postnatal mammalian brain. | Sonego, M., et al. 2015. PLoS One. 10: e0126478. PMID: 25945928
- Drebrin A regulates hippocampal LTP and hippocampus-dependent fear learning in adult mice. | Kojima, N., et al. 2016. Neuroscience. 324: 218-26. PMID: 26970584
- Drebrin E regulates neuroblast proliferation and chain migration in the adult brain. | Kajita, Y., et al. 2017. Eur J Neurosci. 46: 2214-2228. PMID: 28833685
- CaMKIIβ is localized in dendritic spines as both drebrin-dependent and drebrin-independent pools. | Yamazaki, H., et al. 2018. J Neurochem. 146: 145-159. PMID: 29675826
- Drebrin Autoantibodies in Patients with Seizures and Suspected Encephalitis. | Pitsch, J., et al. 2020. Ann Neurol. 87: 869-884. PMID: 32196746
- The drebrin/EB3 pathway regulates cytoskeletal dynamics to drive neuritogenesis in embryonic cortical neurons. | Poobalasingam, T., et al. 2022. J Neurochem. 160: 185-202. PMID: 34478582
- Drebrin Regulates Acetylcholine Receptor Clustering and Organization of Microtubules at the Postsynaptic Machinery. | Alvarez-Suarez, P., et al. 2021. Int J Mol Sci. 22: PMID: 34502296
- Drebrin Regulates Collateral Axon Branching in Cortical Layer II/III Somatosensory Neurons. | Dorskind, JM., et al. 2023. J Neurosci. 43: 7745-7765. PMID: 37798130
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Drebrin Antibody (B-6) | sc-393097 | 200 µg/ml | $322.00 | |||
Drebrin Antibody (B-6): m-IgG Fc BP-HRP Bundle | sc-538140 | 200 µg Ab; 10 µg BP | $361.00 | |||
Drebrin Antibody (B-6): m-IgGκ BP-HRP Bundle | sc-535699 | 200 µg Ab; 40 µg BP | $361.00 | |||
Drebrin Antibody (B-6): m-IgG1 BP-HRP Bundle | sc-545543 | 200 µg Ab; 20 µg BP | $361.00 |