DJ-1 Antibody (A-9): sc-55573
- DJ-1 Antibody (A-9) is a mouse monoclonal IgG2a κ, cited in 7 publications, provided at 200 µg/ml
- raised against amino acids 1-189 representing full length DJ-1 of human origin
- recommended for detection of DJ-1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See DJ-1 (D-4): sc-55572 for DJ-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgGκ BP-HRP is the preferred secondary detection reagent for DJ-1 Antibody (A-9) for WB and IHC(P) applications. This reagent is now offered in a bundle with DJ-1 Antibody (A-9) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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DJ-1 Antibody (A-9) is a mouse monoclonal IgG antibody that detects DJ-1 in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). DJ-1 is a highly-conserved protein that plays a crucial role in cellular processes, particularly in protecting cells from oxidative stress and maintaining mitochondrial function. DJ-1′s ability to regulate the androgen receptor by forming a complex with PIASxα highlights DJ-1′s importance in hormonal signaling pathways, which can have significant implications in both cancer biology and neurodegenerative diseases. The gene encoding DJ-1 is located on chromosome 1p36.23, a region associated with various chromosomal abnormalities in tumor cells, and mutations in this gene have been linked to Parkinson′s disease, underscoring DJ-1′s relevance in neuroprotection. DJ-1 is ubiquitously expressed and translocates from the cytoplasm to the nucleus during the S phase of the cell cycle, indicating DJ-1′s dynamic role in cellular responses to growth stimuli. With multifaceted functions and implications in disease, anti-DJ-1 antibody (A-9) serves as an essential tool for researchers investigating the molecular mechanisms underlying various pathologies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
DJ-1 Antibody (A-9) References:
- DJ-1 as a human oncogene and potential therapeutic target. | Cao, J., et al. 2015. Biochem Pharmacol. 93: 241-50. PMID: 25498803
- Expression of DJ-1 in Cancer Cells: Its Correlation with Clinical Significance. | Kawate, T., et al. 2017. Adv Exp Med Biol. 1037: 45-59. PMID: 29147902
- Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease. | Dolgacheva, LP., et al. 2019. J Bioenerg Biomembr. 51: 175-188. PMID: 31054074
- DJ-1 depletion prevents immunoaging in T-cell compartments. | Zeng, N., et al. 2022. EMBO Rep. 23: e53302. PMID: 35037711
- Modulation of signaling pathways by DJ-1: An updated overview. | Neves, M., et al. 2022. Redox Biol. 51: 102283. PMID: 35303520
- DJ-1 governs airway progenitor cell/eosinophil interactions to promote allergic inflammation. | Li, K., et al. 2022. J Allergy Clin Immunol. 150: 1178-1193.e13. PMID: 35724763
- DJ-1 inhibits glutathione degradation by downregulating CHAC1 expression in astrocytes. | Ge, Y., et al. 2022. Neurosci Res. 184: 62-69. PMID: 35988816
- DJ-1 Molecular Chaperone Activity Depresses Tau Aggregation Propensity through Interaction with Monomers. | Jimenez-Harrison, D., et al. 2023. Biochemistry. 62: 976-988. PMID: 36813261
- Effects of DJ‑1 on apoptosis and mitophagy of glomerular podocytes. | Xiao, J., et al. 2023. Exp Ther Med. 26: 463. PMID: 37664676
- DJ-1 protects cell death from a mitochondrial oxidative stress due to GBA1 deficiency. | Nam, Y., et al. 2024. Genes Genomics. 46: 519-529. PMID: 38460098
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DJ-1 Antibody (A-9) | sc-55573 | 200 µg/ml | $322.00 | |||
DJ-1 Antibody (A-9): m-IgGκ BP-HRP Bundle | sc-521022 | 200 µg Ab, 40 µg BP | $361.00 |