CtIP Antibody (E-2): sc-48415
- CtIP Antibody (E-2) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 598-897 of CtIP of human origin
- recommended for detection of CtIP of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CtIP Antibody (E-2) for WB applications. These reagents are now offered in bundles with CtIP Antibody (E-2) (see ordering information below).
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CtIP Antibody (E-2) is a mouse monoclonal IgG2a light chain antibody that detects CtIP in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CtIP, or C-terminal binding protein interacting protein, plays a crucial role in DNA damage response and repair, particularly in breast cancer, where CtIP interacts with the breast cancer gene BRCA1. This interaction regulates the transcription of the p21 gene, which is essential for cell cycle control and apoptosis in response to DNA damage. CtIP binding to BRCA1 through BRCT repeats modulates BRCA1′s activity, thereby influencing cellular response to genotoxic stress. CtIP′s importance in maintaining genomic stability highlights anti-CtIP antibody (E-2) as an invaluable tool for researchers studying DNA repair mechanisms and their implications in cancer biology.
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CtIP Antibody (E-2) References:
- Ctp1/CtIP and the MRN complex collaborate in the initial steps of homologous recombination. | Takeda, S., et al. 2007. Mol Cell. 28: 351-2. PMID: 17996697
- DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints. | You, Z. and Bailis, JM. 2010. Trends Cell Biol. 20: 402-9. PMID: 20444606
- CtIP-mediated resection is essential for viability and can operate independently of BRCA1. | Polato, F., et al. 2014. J Exp Med. 211: 1027-36. PMID: 24842372
- BRCA1 accelerates CtIP-mediated DNA-end resection. | Cruz-García, A., et al. 2014. Cell Rep. 9: 451-9. PMID: 25310973
- Hepatitis B Virus Infection Dampens CtIP Expression in Hepatoma Cell. | Zhang, D., et al. 2018. J Cancer. 9: 1182-1187. PMID: 29675099
- CTCF cooperates with CtIP to drive homologous recombination repair of double-strand breaks. | Hwang, SY., et al. 2019. Nucleic Acids Res. 47: 9160-9179. PMID: 31340001
- ATM controls the extent of DNA end resection by eliciting sequential posttranslational modifications of CtIP. | Han, J., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 33723063
- CtIP suppresses primary microRNA maturation and promotes metastasis of colon cancer cells in a xenograft mouse model. | Ren, J., et al. 2021. J Biol Chem. 296: 100707. PMID: 33901493
- NBS1-CtIP-mediated DNA end resection suppresses cGAS binding to micronuclei. | Abdisalaam, S., et al. 2022. Nucleic Acids Res. 50: 2681-2699. PMID: 35189637
- CtIP regulates G2/M transition and bipolar spindle assembly during mouse oocyte meiosis. | Yue, W., et al. 2024. J Genet Genomics. 51: 1435-1446. PMID: 39277031
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CtIP Antibody (E-2) | sc-48415 | 200 µg/ml | $322.00 | |||
CtIP Antibody (E-2): m-IgG Fc BP-HRP Bundle | sc-536836 | 200 µg Ab; 10 µg BP | $361.00 | |||
CtIP Antibody (E-2): m-IgGκ BP-HRP Bundle | sc-534003 | 200 µg Ab; 40 µg BP | $361.00 | |||
CtIP Antibody (E-2): m-IgG2a BP-HRP Bundle | sc-547880 | 200 µg Ab; 10 µg BP | $361.00 |