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Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US, Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxesShips via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal health products, bulky and/or heavy items
The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. CLK3 (CDC-like kinase 3), also known as PHCLK3, is a 638 amino acid nuclear and cytoplasmic protein that belongs to the Ser/Thr protein kinase family. Functioning as a dual-specificity kinase, CLK3 catalyzes the ATP-dependent phosphorylation of argine- and serine-rich (SR) splicing factor proteins, thereby regulating both their function and their intranuclear distribution. Via its enzymatic activity, CLK3 is thought to be one of several members of a network of regulatory proteins that control RNA splicing events. Four isoforms of CLK3 exist due to alternative splicing.
Especies | Nombre del Gen | Gen ID | Ubicación en el cromosoma | Numero de Acceso de Isoforma (ARNm) | Número de Acceso de la Proteína | Número OMIM™ |
---|---|---|---|---|---|---|
Human | CLK3 | 1198 | 15q24.1 | XM_005254151, XM_011521205, XM_011521206, XM_011521209, XM_017021905, XM_017021906, XM_017021907, XM_017021908, XM_017021909, XM_017021910, NM_001130028, NM_003992, NM_001292 | P49761 | 602990 |
Mouse | Clk3 | 102414 | 9 B | XM_006510739, XM_017313060, XM_017313061, NM_007713 | O35492 | N/A |