CD1B Antibody (VPM5): sc-101618

CD1B Antibody (VPM5) is a mouse monoclonal IgM antibody that detects CD1B in ovine, caprine, and bovine species through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD1B is a crucial member of the CD1 multigene family, which encodes glycoproteins that play a significant role in the immune response by presenting lipid antigens to T lymphocytes. CD1B (VPM5) antibody recognizes CD1B primarily on the surface of antigen-presenting cells, including dendritic cells and Langerhans cells, where CD1B facilitates the recognition of lipid-based antigens by T cells. Proper localization of CD1B is essential for effective immune surveillance and response, as CD1B ensures that lipid antigens are presented in the right cellular context, allowing for the activation of CD1-restricted T cells. CD1B′s interaction with β-2-Microglobulin is vital for stability and surface expression, further underscoring CD1B′s importance in the immune system. The human CD1 genes, including CD1B, are clustered on chromosome 1q 22-23, highlighting their evolutionary relationship and functional interdependence. With detection capabilities across multiple species and applications, anti-CD1B antibody (VPM5) serves as an invaluable tool for researchers studying lipid antigen presentation and T cell activation in various animal models.

The preferred CD1B antibody is CD1B Antibody (O249): sc-19997.