CD154 Antibody (E-8): sc-74448
- CD154 Antibody (E-8) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 47-261 of CD154 of human origin
- recommended for detection of CD154 of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for CD154 Antibody (E-8) for WB applications. These reagents are now offered in bundles with CD154 Antibody (E-8) (see ordering information below).
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CD154 Antibody (E-8) is a mouse monoclonal IgG1 antibody that detects CD154 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CD154, also known as CD40 ligand, plays a crucial role in the immune response by facilitating communication between T cells and B cells, which is essential for effective antibody production. CD154 is primarily located on the surface of activated T cells, where CD154 interacts with CD40 on B cells, triggering a cascade of signaling events that lead to B cell activation, proliferation, and differentiation into antibody-secreting plasma cells. CD154-CD40 interaction not only promotes immunoglobulin class switching but also enhances the overall adaptive immune response. Dysregulation of CD154 expression can lead to severe immunological disorders, including hyper-IgM immunodeficiency syndrome type 1, highlighting CD154′s critical role in maintaining immune homeostasis. Anti-CD154 antibody (E-8) serves as an invaluable tool for researchers studying immune responses, B cell activation, and related pathologies.
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CD154 Antibody (E-8) References:
- Central role for CD40/CD40 ligand (CD154) interactions in transplant rejection. | Denton, MD., et al. 1998. Pediatr Transplant. 2: 6-15. PMID: 10084754
- CD40-CD154 interaction in experimental and human disease (review). | Biancone, L., et al. 1999. Int J Mol Med. 3: 343-53. PMID: 10085405
- CD154-CD40 interactions mediate differentiation to plasma cells in healthy individuals and persons with systemic lupus erythematosus. | Grammer, AC. and Lipsky, PE. 2002. Arthritis Rheum. 46: 1417-29. PMID: 12115170
- The CD40-CD154 interaction in B cell-T cell liaisons. | Bishop, GA. and Hostager, BS. 2003. Cytokine Growth Factor Rev. 14: 297-309. PMID: 12787567
- CD154-CD40-induced reactivation of latent HIV-1 infection. | Kutsch, O., et al. 2003. Virology. 314: 261-70. PMID: 14517079
- The role of CD40-CD154 interaction in cell immunoregulation. | Xu, Y. and Song, G. 2004. J Biomed Sci. 11: 426-38. PMID: 15153777
- CD154 gene therapy for human B-cell malignancies. | Messmer, D. and Kipps, TJ. 2005. Ann N Y Acad Sci. 1062: 51-60. PMID: 16461788
- Counteractive functions are encrypted in the residues of CD154. | Bandyopadhyay, S., et al. 2015. Hum Immunol. 76: 673-80. PMID: 26429321
- CD154 inhibits death of T cells via a Cis interaction with the α5β1 integrin. | Bachsais, M., et al. 2020. PLoS One. 15: e0235753. PMID: 32745080
- Insights into CD154-mediated pathways in ocular hypertensive glaucoma: The role of Müller cells and P2X7 in retinal neuroprotection and therapeutic potential. | Hu, H., et al. 2023. Cell Biol Int. 47: 1441-1452. PMID: 37132435
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD154 Antibody (E-8) | sc-74448 | 200 µg/ml | $322.00 | |||
CD154 Antibody (E-8): m-IgG Fc BP-HRP Bundle | sc-539522 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD154 Antibody (E-8): m-IgG1 BP-HRP Bundle | sc-541543 | 200 µg Ab; 20 µg BP | $361.00 |