ALCAM Antibody (H-9): sc-74557

ALCAM Antibody (H-9) is a mouse monoclonal IgG2b antibody that detects activated leukocyte cell adhesion molecule (ALCAM) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). ALCAM plays a crucial role in immune responses by facilitating the adhesion of activated leukocytes, such as T cells, B cells, and monocytes, to other cells, which is essential for effective immune surveillance and response. ALCAM is primarily located on the surface of activated leukocytes, where anti-ALCAM antibody (H-9) can detect both homophilic interactions with other ALCAM molecules and heterophilic interactions with CD6, a type I membrane protein that enhances T cell adhesion and costimulation. The interaction between ALCAM and CD6 is particularly significant as ALCAM contributes to the formation of immunological synapses, which are critical for T cell activation and function. ALCAM (H-9) antibody enables researchers to gain insights into the mechanisms of immune cell interactions and their implications in various diseases, including autoimmune disorders and cancer.

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ALCAM Antibody (H-9) References:

1. Activated leukocyte cell adhesion molecule (ALCAM or CD166) modulates bone phenotype and hematopoiesis.  |  Hooker, RA., et al. 2015. J Musculoskelet Neuronal Interact. 15: 83-94. PMID: 25730656
2. Activated Leukocyte Cell Adhesion Molecule Stimulates the T-Cell Response in Allergic Asthma.  |  Kim, MN., et al. 2018. Am J Respir Crit Care Med. 197: 994-1008. PMID: 29394080
3. Activated Leukocyte Cell Adhesion Molecule Modulates Th2 Immune Response in Atopic Dermatitis.  |  Oh, MS., et al. 2019. Allergy Asthma Immunol Res. 11: 677-690. PMID: 31332979
4. The role of activated leukocyte cell adhesion molecule (ALCAM) in cancer progression, invasion, metastasis and recurrence: A novel cancer stem cell marker and tumor-specific prognostic marker.  |  Darvishi, B., et al. 2020. Exp Mol Pathol. 115: 104443. PMID: 32380056
5. ALCAM/CD166: A pleiotropic mediator of cell adhesion, stemness and cancer progression.  |  Ferragut, F., et al. 2021. Cytokine Growth Factor Rev. 61: 27-37. PMID: 34272152
6. The Clinical and Theranostic Values of Activated Leukocyte Cell Adhesion Molecule (ALCAM)/CD166 in Human Solid Cancers.  |  Yang, Y., et al. 2021. Cancers (Basel). 13: PMID: 34680335
7. The CD6/ALCAM pathway promotes lupus nephritis via T cell-mediated responses.  |  Chalmers, SA., et al. 2022. J Clin Invest. 132: PMID: 34981775
8. Activated leukocyte cell adhesion molecule (ALCAM)/CD166 in pancreatic cancer, a pivotal link to clinical outcome and vascular embolism.  |  Yang, Y., et al. 2021. Am J Cancer Res. 11: 5917-5932. PMID: 35018233
9. Activated Leukocyte Cell Adhesion Molecule (ALCAM), a Potential 'Seed' and 'Soil' Receptor in the Peritoneal Metastasis of Gastrointestinal Cancers.  |  Yang, YM., et al. 2023. Int J Mol Sci. 24: PMID: 36614319
10. ALCAM, Activated Leukocyte Cell Adhesion Molecule, in Clinical Gastric Cancer and Patient's Response to Chemotherapies.  |  Yang, YM., et al. 2023. Anticancer Res. 43: 1463-1475. PMID: 36974802

The preferred ALCAM antibody is ALCAM Antibody (B-6): sc-74558.