2900008C10Rik Inhibitors
Bcor inhibitors are a group of compounds that indirectly affect the Bcor protein through various mechanisms related to chromatin modification and transcription regulation. Bcor is a corepressor protein that interacts with several transcription factors, most notably BCL6, to mediate transcriptional repression. The inhibitors listed, such as JQ1, I-BET151, and PFI-1, target the bromodomain and extra-terminal (BET) family proteins, which are known to regulate gene expression through interaction with acetylated histones. By inhibiting the BET proteins, these compounds can disrupt the formation of Bcor-containing chromatin remodeling complexes, thereby influencing Bcor's ability to repress transcription.
The second class of compounds, including A-485, MS-275, SAHA, and CPI-455, function by modulating the acetylation and methylation states of histones. These modifications are crucial for the regulation of gene expression and chromatin structure. Inhibiting histone acetyltransferases (HATs) like p300/CBP with A-485, or histone deacetylases (HDACs) with MS-275 and SAHA, can lead to altered histone acetylation. This in turn can affect the binding of Bcor to chromatin and its interaction with other transcriptional repressors. Similarly, compounds like GSK343 and UNC1999 inhibit EZH2, a histone methyltransferase, and can thereby influence the methylation landscape of chromatin associated with Bcor function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
Bromodomain inhibitor that can disrupt the interaction between Bcor and other transcription factors like BCL6, affecting its corepressor function. | ||||||
I-BET 151 Hydrochloride | 1300031-49-5 (non HCl Salt) | sc-391115 | 10 mg | $450.00 | 2 | |
BET bromodomain inhibitor that can prevent the assembly of Bcor-containing repressive complexes on chromatin. | ||||||
PFI-1 | 1403764-72-6 | sc-478504 | 5 mg | $98.00 | ||
Another BET inhibitor that can interfere with Bcor recruiting its associated factors, potentially inhibiting its repressor function. | ||||||
SGC-CBP30 | 1613695-14-9 | sc-473871 sc-473871A | 5 mg 10 mg | $178.00 $338.00 | ||
A CBP/p300 bromodomain inhibitor which might disrupt Bcor's interaction with acetylated lysines on histones and transcription factors. | ||||||
(S)-2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-hydroxyphenyl)acetamide | 202590-98-5 | sc-501130 | 2.5 mg | $330.00 | ||
A methyltransferase inhibitor that indirectly affects Bcor function through chromatin remodeling. | ||||||
A-485 | 1889279-16-6 | sc-507493 | 5 mg | $275.00 | ||
A potent and selective p300/CBP histone acetyltransferase inhibitor, can modulate chromatin structure and affect Bcor's corepressor activity. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
Histone deacetylase inhibitor, can alter the acetylation status of histones and disrupt Bcor-mediated chromatin modifications. | ||||||
GSK343 | 1346704-33-3 | sc-397025 sc-397025A | 5 mg 25 mg | $151.00 $461.00 | 1 | |
EZH2 inhibitor that can affect the methylation status of histones, potentially disrupting Bcor's recruitment to chromatin. | ||||||
UNC1999 | 1431612-23-5 | sc-475314 | 5 mg | $142.00 | 1 | |
A selective inhibitor of EZH2 and EZH1, can modulate histone methylation and possibly affect Bcor's function. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Histone deacetylase inhibitor that increases acetylation levels, potentially affecting Bcor's ability to repress transcription. | ||||||