TRAF2 Antibody (F-4): sc-137048
- TRAF2 Antibody (F-4) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1-249 of TRAF2 of human origin
- recommended for detection of TRAF2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See TRAF2 (F-2): sc-136999 for TRAF2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TRAF2 Antibody (F-4) for WB and IHC(P) applications. These reagents are now offered in bundles with TRAF2 Antibody (F-4) (see ordering information below).
TRAF2 Antibody (F-4) is a mouse monoclonal IgG1 antibody that detects TRAF2 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). TRAF2 plays a crucial role in mediating tumor necrosis factor (TNF) receptor signaling, particularly through interaction with TNF receptor 1 (TNF-R1) and TNF receptor 2 (TNF-R2), which are integral to the TNF receptor superfamily. TRAF2 forms heterodimeric complexes with TRAF1 and other associated proteins, facilitating downstream signaling pathways that regulate inflammation, cell survival, and apoptosis. TRAF2 interacts with various signaling molecules, underscoring its role in the immune response and potential implications in diseases such as cancer and autoimmune disorders. The TRAF-C domain of TRAF2 is essential for binding to the cytoplasmic domains of TNF receptors and other proteins, thereby influencing cellular responses to TNF signaling. With broad species reactivity and versatility in applications, anti-TRAF2 antibody (F-4) serves as an invaluable tool for researchers studying TNF receptor-mediated signaling pathways and their implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TRAF2 Antibody (F-4) References:
- Physiological roles and mechanisms of signaling by TRAF2 and TRAF5. | Au, PY. and Yeh, WC. 2007. Adv Exp Med Biol. 597: 32-47. PMID: 17633015
- RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer. | Schneider, AT., et al. 2017. Cancer Cell. 31: 94-109. PMID: 28017612
- TRAF2 is a Valuable Prognostic Biomarker in Patients with Prostate Cancer. | Wei, B., et al. 2017. Med Sci Monit. 23: 4192-4204. PMID: 28855498
- Pro-apoptotic functions of TRAF2 in p53-mediated apoptosis induced by cisplatin. | Tsuchida, M., et al. 2020. J Toxicol Sci. 45: 219-226. PMID: 32238696
- Fish TRAF2 promotes innate immune response to RGNNV infection. | Li, C., et al. 2020. Fish Shellfish Immunol. 102: 108-116. PMID: 32311458
- SMYD2-mediated TRAF2 methylation promotes the NF-κB signaling pathways in inflammatory diseases. | Wu, W., et al. 2021. Clin Transl Med. 11: e591. PMID: 34841684
- SNHG15 is a negative regulator of inflammation by mediating TRAF2 ubiquitination in stroke-induced immunosuppression. | Sun, H., et al. 2022. J Neuroinflammation. 19: 1. PMID: 34980176
- Characterization of TRAF2 in Nile tilapia: Expression profiles and the role in decreasing NF-κB pathway. | Hu, H., et al. 2022. Fish Shellfish Immunol. 122: 13-20. PMID: 35051565
- TRAF2, an Innate Immune Sensor, Reciprocally Regulates Mitophagy and Inflammation to Maintain Cardiac Myocyte Homeostasis. | Ma, X., et al. 2022. JACC Basic Transl Sci. 7: 223-243. PMID: 35411325
- Inhibition of Endoplasmic Reticulum Stress Improves Chronic Ischemic Hippocampal Damage Associated with Suppression of IRE1α/TRAF2/ASK1/JNK-Dependent Apoptosis. | Kang, K., et al. 2024. Inflammation. 47: 1479-1490. PMID: 38401021
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TRAF2 Antibody (F-4) | sc-137048 | 200 µg/ml | $322.00 | |||
TRAF2 Antibody (F-4): m-IgG Fc BP-HRP Bundle | sc-537395 | 200 µg Ab; 10 µg BP | $361.00 | |||
TRAF2 Antibody (F-4): m-IgGκ BP-HRP Bundle | sc-534649 | 200 µg Ab; 40 µg BP | $361.00 | |||
TRAF2 Antibody (F-4): m-IgG1 BP-HRP Bundle | sc-545172 | 200 µg Ab; 20 µg BP | $361.00 |