Stat2 Antibody (A-9): sc-166201
- Stat2 Antibody (A-9) is a mouse monoclonal IgG1 κ, cited in 6 publications, provided at 200 µg/ml
- raised against amino acids 662-851 of Stat2 of human origin
- recommended for detection of Stat2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- TransCruz reagent for ChIP application (sc-166201 X, 200 µg/0.1 ml)
- See Stat2 (B-3): sc-514193 for Stat2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Stat2 Antibody (A-9) for WB and IHC(P) applications. These reagents are now offered in bundles with Stat2 Antibody (A-9) (see ordering information below).
Stat2 Antibody (A-9) is a mouse monoclonal IgG1 antibody that detects Stat2 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Stat2 plays a crucial role in the immune response and is primarily involved in mediating the effects of interferons, which are vital for antiviral defense and immune regulation. Upon activation by interferons, Stat2 forms a heterodimer with Stat1, contributing to the formation of the ISGF3 transcription factor complex that regulates the expression of genes involved in immune responses. The proper functioning of Stat2 is essential for the transcriptional activation of interferon-stimulated genes, which are critical for establishing an effective antiviral state in cells. Dysregulation of Stat2 signaling has been implicated in various diseases, including autoimmune disorders and cancers, highlighting its importance as a therapeutic target. Anti-Stat2 antibody (A-9) is an invaluable tool for researchers studying the intricate signaling pathways involved in immune responses and the role of Stat proteins in cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Stat2 Antibody (A-9) References:
- STAT2 phosphorylation and signaling. | Steen, HC. and Gamero, AM. 2013. JAKSTAT. 2: e25790. PMID: 24416652
- STAT2 signaling and dengue virus infection. | Morrison, J. and García-Sastre, A. 2014. JAKSTAT. 3: e27715. PMID: 24778924
- STAT2-directed pathogen responses. | Bluyssen, H. 2015. Oncotarget. 6: 28525-6. PMID: 26337339
- Stat2 stability regulation: an intersection between immunity and carcinogenesis. | Lee, CJ., et al. 2020. Exp Mol Med. 52: 1526-1536. PMID: 32973222
- circCAPRIN1 interacts with STAT2 to promote tumor progression and lipid synthesis via upregulating ACC1 expression in colorectal cancer. | Yang, Y., et al. 2023. Cancer Commun (Lond). 43: 100-122. PMID: 36328987
- STAT2/Caspase3 in the diagnosis and treatment of psoriasis. | Fu, Z., et al. 2023. Eur J Clin Invest. 53: e13959. PMID: 36708067
- Human inherited complete STAT2 deficiency underlies inflammatory viral diseases. | Bucciol, G., et al. 2023. J Clin Invest. 133: PMID: 36976641
- STAT2 hinders STING intracellular trafficking and reshapes its activation in response to DNA damage. | Wang, C., et al. 2023. Proc Natl Acad Sci U S A. 120: e2216953120. PMID: 37036972
- STAT2 Controls Colorectal Tumorigenesis and Resistance to Anti-Cancer Drugs. | Chiriac, MT., et al. 2023. Cancers (Basel). 15: PMID: 38001683
- Zika virus NS5 protein inhibits type I interferon signaling via CRL3 E3 ubiquitin ligase-mediated degradation of STAT2. | Ren, W., et al. 2024. Proc Natl Acad Sci U S A. 121: e2403235121. PMID: 39145933
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Stat2 Antibody (A-9) | sc-166201 | 200 µg/ml | $322.00 | |||
Stat2 Antibody (A-9): m-IgG Fc BP-HRP Bundle | sc-540043 | 200 µg Ab; 10 µg BP | $361.00 | |||
Stat2 Antibody (A-9): m-IgG1 BP-HRP Bundle | sc-541864 | 200 µg Ab; 20 µg BP | $361.00 | |||
Stat2 Antibody (A-9) X | sc-166201 X | 200 µg/0.1 ml | $322.00 |