Date published: 2026-5-3
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SDF-1/CXCL12 Antibody (P-159X): sc-74271

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Datasheets
  • SDF-1/CXCL12 Antibody (P-159X) is a mouse monoclonal IgG1 κ, cited in 27 publications, provided at 50 µg/0.5 ml
  • raised against amino acids 20-89 of SDF-1 of human origin
  • recommended for detection of SDF-1α and SDF-1β of mouse, rat and human origin by WB, IF and IHC(P)
  • At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SDF-1/CXCL12 Antibody (P-159X). This work is in progress.
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Additional SDF Antibodies including SDF-1, SDF-2 and SDF-4

SDF-1 Antibody (P-159X) is a mouse monoclonal IgG1 antibody that detects SDF-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunofluorescence (IF), and immunohistochemistry. SDF-1, also known as CXCL12, plays a crucial role in the immune response by acting as a potent chemoattractant for T cells and monocytes, facilitating their migration to sites of inflammation or injury. SDF-1 is primarily located in the extracellular space and is secreted by various cell types, including stromal cells, which underscores SDF-1′s importance in the regulation of immune cell trafficking and tissue homeostasis. Notably, SDF-1 exists in six human isoforms due to alternative splicing, which allows for diverse functional roles in different physiological contexts. The interaction of SDF-1 with CXCR-4 receptor is particularly significant as SDF-1 has been identified as a major co-receptor for T-tropic HIV-1, highlighting SDF-1′s relevance in both immune response and viral pathogenesis. Anti-SDF-1 antibody (P-159X) is an essential tool for researchers studying the dynamics of immune cell migration and the implications of SDF-1 in various diseases, including cancer and HIV infection.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

SDF-1/CXCL12 Antibody (P-159X) References:

  1. CXCL12 (SDF-1)/CXCR4 pathway in cancer.  |  Teicher, BA. and Fricker, SP. 2010. Clin Cancer Res. 16: 2927-31. PMID: 20484021
  2. Targeting SDF-1 in multiple myeloma tumor microenvironment.  |  Bouyssou, JM., et al. 2016. Cancer Lett. 380: 315-8. PMID: 26655999
  3. Stromal cell-derived factor-1 (SDF-1) as a target in liver diseases.  |  Liepelt, A. and Tacke, F. 2016. Am J Physiol Gastrointest Liver Physiol. 311: G203-9. PMID: 27313175
  4. The Role of SDF-1/CXCR4/CXCR7 in Neuronal Regeneration after Cerebral Ischemia.  |  Cheng, X., et al. 2017. Front Neurosci. 11: 590. PMID: 29123467
  5. SDF-1 modulates periodontal ligament-Mesenchymal Stem Cells (pdl-MSCs).  |  Hakki, SS., et al. 2021. J Periodontal Res. 56: 774-781. PMID: 33733508
  6. Modifying strategies for SDF-1/CXCR4 interaction during mesenchymal stem cell transplantation.  |  Jiang, Q., et al. 2022. Gen Thorac Cardiovasc Surg. 70: 1-10. PMID: 34510332
  7. The significance of the SDF-1/CXCR4 signaling pathway in the normal development.  |  Sadri, F., et al. 2022. Mol Biol Rep. 49: 3307-3320. PMID: 35067815
  8. SDF-1 Functionalized Hydrogel Microcarriers for Skin Flap Repair.  |  Liu, X., et al. 2022. ACS Biomater Sci Eng. 8: 3576-3588. PMID: 35899941
  9. Targeting SDF-1 as an efficient strategy to resolve skin hyperpigmentation issues with Himanthalia elongata extract.  |  Meunier, M., et al. 2023. J Cosmet Dermatol. 22: 383-394. PMID: 36062379
  10. SDF-1 and NOTCH signaling in myogenic cell differentiation: the role of miRNA10a, 425, and 5100.  |  Mierzejewski, B., et al. 2023. Stem Cell Res Ther. 14: 204. PMID: 37582765

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

SDF-1/CXCL12 Antibody (P-159X)

sc-74271
50 µg/0.5 ml
$322.00

I need to use an antibody to detect the protein in samples of avian origin. Do you know if this mouse monoclonal antibody will work?

Asked by: jerojero
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Tech Service 3
Date published: 2017-02-02
  • y_2026, m_4, d_29, h_11CST
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Rated 3 out of 5 by from works wellthe product came as a replacement for a lot that didn't work in our hands. It worked well this time with nitrocellulose membrane. It didn't work when we used PVDF membrane. We get 2 bands.
Date published: 2017-11-16
Rated 5 out of 5 by from well performedThis antibody works well in IHC on human parafin sections.The sections deparafinized, but no antigen retrieval were used.The antibody was used in a 1:200 dilution
Date published: 2017-07-23
Rated 5 out of 5 by from no background , good qualityLoading 50ug Hela cell lysates, the antibody diluted at 1:600 ,the seconary diluted at 1:5000,both incubated at roo temperature for 2hour.clear band and no background.
Date published: 2017-06-24
Rated 5 out of 5 by from Robust signalRobust signal seen in WB in human transfected 293T whole cell lysates.
Date published: 2017-06-01
Rated 5 out of 5 by from good productSanta antibody samples provide excellent results, Great product! Very clean!
Date published: 2017-02-11
Rated 5 out of 5 by from Highly recommendedVersatile antibody! Cited in multiple publications for use in ELISA, WB, IHC (P) and IF
Date published: 2017-01-05
Rated 5 out of 5 by from Great WBApplied in western blot to detect mouse brain，It shows single and clear ~10 kDa band，Dilution is 1:200.
Date published: 2016-12-17
Rated 4 out of 5 by from Produced publishable sandwich ELISA dataProduced publishable sandwich ELISA data with mouse hippocampi were dissected from postnatal mice - SCBT Publication Review
Date published: 2015-03-24
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SDF-1/CXCL12 Antibody (P-159X) is rated 4.5 out of 5 by 10.
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