RCC1 Antibody (F-2): sc-376049

RCC1 Antibody (F-2) is a mouse monoclonal IgG2b antibody that detects RCC1 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). RCC1, or regulator of chromosome condensation 1, plays a crucial role in the regulation of the small Ras-related protein Ran, which is essential for multiple cellular processes such as DNA replication, mitosis, and the transport of RNA and proteins across the nuclear pore complex. RCC1 is primarily located in the nucleus, where RCC1 acts as a guanine nucleotide exchange factor, facilitating the conversion of inactive Ran GDP to its active form, Ran GTP. This conversion is vital for maintaining the proper balance of Ran GTP and GDP, which is necessary for the efficient transport of molecules into and out of the nucleus. RCC1′s activity is tightly regulated by various proteins, including Ran GAP1, which promotes the hydrolysis of Ran GTP, and Ran BP1, which inhibits RCC1′s activity, thereby influencing the dynamics of nuclear transport. Anti-RCC1 antibody (F-2) is an invaluable tool for researchers studying the intricate mechanisms of nuclear transport and the role of Ran in cellular function.

The preferred RCC1 antibody is RCC1 Antibody (E-6): sc-55559.