PTTG Antibody (G-9): sc-376454
- PTTG Antibody (G-9) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 13-47 near the N-terminus of PTTG of human origin
- recommended for detection of PTTG of mouse, rat and human origin by WB, IP, IF and ELISA
- See PTTG (DCS-280): sc-56207 for PTTG antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for PTTG Antibody (G-9) for WB applications. This reagent is now offered in a bundle with PTTG Antibody (G-9) (see ordering information below).
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SEE ALSO...
PTTG Antibody (G-9) is a mouse monoclonal IgG1 antibody that detects pituitary tumor transforming gene (PTTG) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PTTG plays a crucial role in cell cycle regulation by acting as an anaphase inhibitor, specifically regulating the separin Esp1, which is essential for chromatid separation during mitosis. This function helps ensure proper chromosome segregation, thereby preventing chromosomal instability, a hallmark of many cancers. PTTG is predominantly expressed in the cytoplasm, with partial localization in the nucleus, and is notably overexpressed in Jurkat cells, as well as detected in human thymus, testis, and placenta. The unique structural features of PTTG, including its basic amino-terminal and acidic carboxy-terminal domains, contribute to its function as a transactivation domain when fused to other DNA binding domains, highlighting its importance in gene regulation and potential implications in oncogenesis. Anti-PTTG antibody (G-9) is an essential tool for researchers studying the mechanisms of cell cycle control and the role of PTTG in cancer biology.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PTTG Antibody (G-9) | sc-376454 | 200 µg/ml | $322.00 | |||
PTTG Antibody (G-9): m-IgG Fc BP-HRP Bundle | sc-540573 | 200 µg Ab; 10 µg BP | $361.00 | |||
PTTG (G-9) Neutralizing Peptide | sc-376454 P | 100 µg/0.5 ml | $69.00 |